{
  "abstract": "BACKGROUND: Tremor affects many people with multiple sclerosis (MS), is frequently disabling and responds poorly to medication. Deep brain stimulation, gamma-knife radiosurgery and MR-guided focused ultrasound are options, but each has constraints. MR-guided laser interstitial thermal therapy (MRgLITT) is a hardware-free stereotactic thalamotomy providing real-time thermometry, its role in MS tremor is unknown. OBJECTIVE: To describe 12-month clinical, safety and imaging outcomes after unilateral MRgLITT thalamotomy for refractory MS tremor. METHODS: Single-centre, consecutive case series of four patients with medically refractory MS tremor who underwent robot-assisted unilateral MRgLITT thalamotomy. The primary outcome was the treated-limb Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS) at 12 months, scored from standardized videos by a blinded neurologist. Secondary outcomes were patient-reported tremor severity, tremor-related quality of life, adverse events, cognition, mood and MRI lesion characteristics. Analyses were descriptive. RESULTS: The cohort comprised three secondary-progressive and one relapsing-remitting patient (median EDSS 5.5; median tremor duration 15.5 years). The mean treated-limb FTM-TRS score fell from 15.8 to 5.5 at 12 months (mean per-patient reduction 65.7%, range 41.2-80.0%). Quality of life improved in three of four patients. Acute adverse events occurred in two patients (transient gait ataxia; transient hemiparesis with dysarthria), both resolving by 3 months, none persisting at 12 months. Cognitive decline in one patient and mood deterioration in two, the causes of these changes remain uncertain. CONCLUSION: Unilateral MRgLITT thalamotomy was feasible and produced meaningful, largely sustained tremor reduction within a narrow therapeutic window. Larger controlled studies are required to establish efficacy, durability, safety and function.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Mickael Aubignat"
    },
    {
      "name": "Mélissa Tir"
    },
    {
      "name": "Martial Ouendo"
    },
    {
      "name": "Ines Masmoudi"
    },
    {
      "name": "Simone Chen"
    },
    {
      "name": "Abdullatif Al Khedr"
    },
    {
      "name": "Jean-Marc Constans"
    },
    {
      "name": "Michel Lefranc"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0054xjk71f92s.bib",
  "cited_by": 0,
  "doi": "10.1016/j.msard.2026.107966",
  "fulltext_url": null,
  "id": "0054xjk71f92s",
  "issns": [
    "2211-0356",
    "2211-0348"
  ],
  "landing_url": "https://u-picardie.hal.science/hal-05785707v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "openalex",
      "2728|Neurological disorders and treatments"
    ]
  ],
  "openalex": "W7220361955",
  "pdf_url": "https://www.msard-journal.com/article/S2211-0348(26)01001-1/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0054xjk71f92s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "hal-05785707",
      "source": "hal",
      "url": "https://u-picardie.hal.science/hal-05785707v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.neu",
      "subfield": "neuroscience"
    }
  ],
  "title": "Unilateral MR-guided laser interstitial thermal therapy thalamotomy for refractory multiple sclerosis tremor: 12-month outcomes in four patients",
  "title_text": "Unilateral MR-guided laser interstitial thermal therapy thalamotomy for refractory multiple sclerosis tremor: 12-month outcomes in four patients",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:50Z",
  "url": "https://research.draconitic.com/paper/0054xjk71f92s",
  "venue": "Multiple Sclerosis and Related Disorders",
  "versions": []
}