{
  "abstract": "Biological ion channels achieve highly selective, ultrafast ion transport through stimulus-responsive gating, in which conformational changes triggered by chemical cues such as pH that modulate channel permeability with exquisite precision. Replicating this coupled chemical-structural functionality in synthetic membranes remains a fundamental challenge, particularly for scalable platforms relevant to energy harvesting, desalination, and chemical sensing. Here, we report a bioinspired polymer-metal-organic framework (MOF) composite membrane in which an amino acid (histidine) functionalized MOF nanopores serve as synthetic proton-gated anion channel. The histidine modified, spatially confined ion transport pathway exhibited selective Cl- diffusion at pH 4, enabling pH programmable control of transmembrane potential. Micrometer-scale percolated transport networks within the composite membrane, architecturally inspired by ion channels embedded in lipid bilayers, translate localized αNH2(histidine)-anion specific interaction into macroscopic, anion selective transmembrane potential output. This work establishes a generalizable design strategy for coupling chemical gating with macroscopic ion transport in synthetic membrane systems, with direct implications for ion separations, sensing and osmotic energy generation.",
  "abstract_shown": true,
  "affiliations": [
    "Tata Institute of Fundamental Research Hyderabad",
    "School of Advanced Sciences, VIT-AP University, Amaravati, Andhra Pradesh, 522241",
    "Radiochemistry Division",
    "Bhabha Atomic Research Centre",
    "Homi Bhabha National Institute"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "KM. Archana Yadav"
    },
    {
      "affs": [
        0
      ],
      "name": "Ritupan Sarmah"
    },
    {
      "affs": [
        1
      ],
      "name": "Bibhab Bandhu Majumdar"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Renjith B. Nelliyil"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Jaideep Mor"
    },
    {
      "affs": [
        0
      ],
      "name": "A R Ramya"
    },
    {
      "affs": [
        0
      ],
      "name": "Mukesh Kumar"
    },
    {
      "affs": [
        0
      ],
      "name": "Prashant Kumar Singh"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Sandeep K. Sharma"
    },
    {
      "affs": [
        0
      ],
      "name": "Jagannath Mondal"
    },
    {
      "affs": [
        0
      ],
      "name": "Tharangattu N Narayanan"
    },
    {
      "affs": [
        0
      ],
      "name": "Ritesh Haldar",
      "orcid": "0000-0001-9697-9169"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/00dfg5r342rfn.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009881/v1",
  "fulltext_url": null,
  "id": "00dfg5r342rfn",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009881/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Nanopore and Nanochannel Transport Studies"
    ]
  ],
  "openalex": "W7220399188",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-05",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/00dfg5r342rfn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15009881",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009881/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "source:chemrxiv",
      "subfield": "general"
    }
  ],
  "title": "pH-responsive nanopores enable programmable transmembrane potential",
  "title_text": "pH-responsive nanopores enable programmable transmembrane potential",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/00dfg5r342rfn",
  "venue": "ChemRxiv",
  "versions": []
}