{
  "abstract": "INTRODUCTION: The Apolipoprotein E ε4 allele (APOE‐ε4) is a well‐established dementia risk factor among non‐Latino White individuals but remains understudied among Asian Americans. We estimated its association with dementia risk among Chinese, Japanese, Filipino, and non‐Latino White older adults in California.\n\nMETHODS: This longitudinal study included 1078 Chinese, 843 Japanese, 583 Filipino, and 43,821 non‐Latino White participants from the Genetic Epidemiology Research in Adult Health and Aging cohort (mean baseline age = 70 years). Dementia was identified using electronic health records. We estimated effects of APOE‐ε4 carriership on dementia risk using pooled logistic regression.\n\nRESULTS: APOE‐ε4 carriership prevalence ranged from 14% among Filipino to 25% among non‐Latino White participants. APOE‐ε4 carriership was associated with higher dementia risk across groups; 10‐year risk ratios (95% confidence interval [CI]) ranged from 1.59 (0.66–3.10) among Filipino to 1.96 (1.36–2.78) among Japanese participants.\n\nDISCUSSION: Despite differences in prevalence of APOE‐ε4, its association with dementia risk was similar across Chinese, Japanese, Filipino, and non‐Latino White participants.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epidemiology, Fielding School of Public Health University of California, Los Angeles Los Angeles California USA",
    "Department of Epidemiology Boston University School of Public Health Boston Massachusetts USA",
    "Department of Biostatistics, Fielding School of Public Health University of California, Los Angeles Los Angeles California USA",
    "Leonard Davis School of Gerontology University of Southern California Los Angeles California USA",
    "Kaiser Permanente Center for Health Research Portland Oregon USA",
    "Department of Epidemiology and Biostatistics University of California, San Francisco San Francisco California USA",
    "Office of Research School of Nursing University of California, San Francisco San Francisco California USA",
    "Department of Integrative Biology and Physiology University of California Los Angeles California USA",
    "Department of Public Health Sciences University of California, Davis Davis California USA",
    "Department of Neurology University of California, Davis Sacramento California USA",
    "Division of Research Kaiser Permanente Northern California Pleasanton California USA",
    "Department of Community Health Sciences, Fielding School of Public Health University of California, Los Angeles Los Angeles California USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yingyan Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "L. Paloma Rojas‐Saunero"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yixuan Zhou"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Eleanor Hayes‐Larson"
    },
    {
      "affs": [
        0
      ],
      "name": "Joseph Oliver Fong"
    },
    {
      "affs": [
        0
      ],
      "name": "Taylor Mobley"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Willa D. Brenowitz"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Thomas J. Hoffmann"
    },
    {
      "affs": [
        7
      ],
      "name": "Kacie D. Deters"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Rachel A. Whitmer"
    },
    {
      "affs": [
        10
      ],
      "name": "Paola Gilsanz"
    },
    {
      "affs": [
        11
      ],
      "name": "Gilbert C. Gee"
    },
    {
      "affs": [
        2
      ],
      "name": "Ron Brookmeyer"
    },
    {
      "affs": [
        0
      ],
      "name": "Elizabeth Rose Mayeda"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/00dwj4gbda6qa.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71615",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13716221/",
  "id": "00dwj4gbda6qa",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://doi.org/10.1002/alz.71615",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7167937900",
  "pdf_url": null,
  "pmcid": "PMC13716221",
  "pmid": "42427166",
  "published": "2026-07-09",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/00dwj4gbda6qa.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:16Z",
      "native_id": "PMC13716221",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71615"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "APOE‐ε4 carriership and dementia risk over 10 years among Asian American and White older adults",
  "title_text": "APOE‐ε4 carriership and dementia risk over 10 years among Asian American and White older adults",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:16Z",
  "url": "https://research.draconitic.com/paper/00dwj4gbda6qa",
  "venue": "Alzheimer's & Dementia",
  "versions": []
}