{
  "abstract": "Accurate assessment of aspiration is critical for managing dysphagia, yet conventional videofluoroscopic swallow study (VFSS) protocols using small fluid volumes may not reflect real-life dietary conditions. This study aimed to evaluate aspiration during large-volume and sequential swallowing tasks in comparison with the standard 5 mL swallow test. We conducted a retrospective single-center observational study using VFSS data from 53 patients with neurogenic dysphagia. A total of 159 swallowing observations from the same 53 patients were analyzed across 3 swallowing conditions (a repeated-measures design): 5 mL swallow, large-volume swallow, and sequential swallowing, all mixed with barium. Aspiration was determined using the Penetration-Aspiration Scale, with a score of ≥5 indicating aspiration. Kinematic parameters, including laryngeal elevation distance, duration, velocity, and pharyngeal transit time, were analyzed. Aspiration occurred in 11 patients during the 5 mL test, and in 16 patients each during both large-volume and sequential swallowing; this difference was not statistically significant in the repeated-measures analysis. Sequential swallowing showed significantly reduced laryngeal elevation distance and duration compared with the other tests, whereas the large-volume test showed significantly greater laryngeal elevation distance and duration than the 5 mL test (P = .005 and P = .011, respectively). Pharyngeal transit time also differed significantly across conditions (P = .003), although the effect size was small (Kendall’s W = 0.107). In the 5 mL condition, patients with aspiration had a significantly slower laryngeal elevation velocity than those without aspiration. In the exploratory within-condition comparisons, no other differences between the aspiration and non-aspiration groups reached statistical significance. These findings suggest that aspiration events were numerically more frequent during the large-volume and sequential swallowing tasks than during the conventional 5 mL test, although this difference was not statistically significant in the repeated-measures analysis. Standard VFSS protocols using small-volume swallows may not fully reflect aspiration patterns encountered during routine eating and drinking. Including large-volume and sequential swallowing tasks during VFSS may provide additional information for the assessment of aspiration risk in patients wishing to return to a regular diet. These findings should be interpreted with caution given the retrospective design and relatively small cohort size.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physical Medicine and Rehabilitation, Jeonbuk National University Medical School, Jeonju, Korea",
    "Research Institute of Clinical Medicine of Jeonbuk National University – Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Byeong-Hun Oh"
    },
    {
      "affs": [
        0
      ],
      "name": "Tae-Seok Chae"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Da-Sol Kim"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu-Hui Won"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sung-Hee Park"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Myoung-Hwan Ko"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jeong-Hwan Seo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gi-Wook Kim",
      "orcid": "0000-0002-1628-8382"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/00g577dsg423t.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051379",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727160/?tool=EBI",
  "id": "00g577dsg423t",
  "issns": [
    "0304-5412",
    "1536-5964",
    "0025-7974"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13727160",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "6300"
    ],
    [
      "heading",
      "Observational Study"
    ],
    [
      "heading",
      "Research Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727160/pdf/?tool=EBI",
  "pmcid": "PMC13727160",
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/00g577dsg423t.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13727160",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727160"
    },
    {
      "first_seen": "2026-11-05T12:23:17Z",
      "native_id": "PMC13727160",
      "source": "pmc",
      "url": "https://doi.org/10.1097/md.0000000000051379"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Association of fluid volume and sequential swallowing method with videofluoroscopic swallow study findings in patients with dysphagia : A retrospective observational study",
  "title_text": "Association of fluid volume and sequential swallowing method with videofluoroscopic swallow study findings in patients with dysphagia : A retrospective observational study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:53Z",
  "url": "https://research.draconitic.com/paper/00g577dsg423t",
  "venue": "Medicine",
  "versions": []
}