{
  "abstract": "Magnetic hyperthermia integrated with magnetic resonance imaging (MRI) requires nanoparticles that combine strong heating, T2 contrast, and hemocompatibility after systemic administration. Here, we prepared citrate-stabilized ferrite nanoparticles (Fe3O4, Co0.6Fe2.4O4, Zn0.3Fe2.7O4, and Zn0.35Mn0.25Fe2.4O4) in spherical (8-10.5 nm) and quasi-cubic (9-12.5 nm) forms, along with 35 nm Fe3O4 cubes. By coupling morphology engineering with spinel-lattice cation substitution, we tuned saturation magnetization, coercivity, T2-weighted signal attenuation, and heat dissipation in ovarian tumor-mimicking phantoms under clinically compatible alternating magnetic fields. The 35 nm Fe3O4 cube and quasi-cubic Zn0.35Mn0.25Fe2.4O4 generated the highest phantom temperature rises, whereas smaller spherical particles produced softer heating. All formulations were cytocompatible in SKOV3 cells, with >96% viability at 24 h. However, hemocompatibility distinguished the leading candidates: 35 nm Fe3O4 cubes induced red blood cell deformation despite minimal hemolysis, while 9 nm quasi-cubic Zn0.35Mn0.25Fe2.4O4 showed no change versus PBS up to 1,000 μg mL-1. Perfusable GelMA models under physiological flow further confirmed biocompatibility. MRI phantoms showed that Fe3O4 cubes produced extended signal voids that may obscure boundaries. Overall, 9.5 nm quasi-cubic Zn0.35Mn0.25Fe2.4O4 is the leading intravenous candidate, combining strong heating, T2 contrast, and hemocompatibility, whereas large Fe3O4 cubes are better suited for localized intratumoral hyperthermia.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2609.14720",
  "author_total": 8,
  "authors": [
    {
      "name": "Bahareh Rezaei"
    },
    {
      "name": "Md Shahriar"
    },
    {
      "name": "Shahriar Mostufa"
    },
    {
      "name": "Karla Mercedes Paz González"
    },
    {
      "name": "Nguyen Thuy Linh Tran"
    },
    {
      "name": "Changxue Xu"
    },
    {
      "name": "Jenifer Gómez-Pastora"
    },
    {
      "name": "Kai Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/00r7hthwxdrv6.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2609.14720",
  "fulltext_url": null,
  "id": "00r7hthwxdrv6",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2609.14720",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "physics.app-ph"
    ],
    [
      "openalex",
      "2204|Characterization and Applications of Magnetic Nanoparticles"
    ]
  ],
  "openalex": "W7213286631",
  "pdf_url": "https://arxiv.org/pdf/2609.14720",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/00r7hthwxdrv6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "2609.14720",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2609.14720"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:physics.app-ph",
      "subfield": "applied-instrumentation"
    }
  ],
  "title": "Shape- and Cation-Engineered Ferrite Nanoparticles for Enhanced Theranostic Performance in Ovarian Cancer Tumor-Mimicking Phantom",
  "title_text": "Shape- and Cation-Engineered Ferrite Nanoparticles for Enhanced Theranostic Performance in Ovarian Cancer Tumor-Mimicking Phantom",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:25Z",
  "url": "https://research.draconitic.com/paper/00r7hthwxdrv6",
  "venue": "arXiv",
  "versions": []
}