{
  "abstract": "Although experimental studies have demonstrated that platelet-rich plasma (PRP) promotes peripheral nerve repair, its clinical efficacy in treating peripheral nerve injuries remains unclear. The present study aims to evaluate safety and functional outcomes of ultrasound-guided PRP injection for peripheral nerve injury. This retrospective study analyzed consecutive patients receiving ultrasound-guided PRP injections for peripheral nerve injuries between January 2021 and March 2025. Outcomes were assessed at 1, 3, and 6 months post-treatment, defined as: (1) a ≥2-point reduction in the Numerical Rating Scale (NRS) for sensory recovery, and (2) a ≥1-grade improvement in the Medical Research Council (MRC) scale for motor function. Patients were divided based on symptom duration into short-duration (<1 year) and long-duration (≥1 year) groups. All procedure-related complications were recorded. Among 48 treated nerves, PRP therapy resulted in gradual functional improvement and was well-tolerated. Sensory recovery rates remained stable (70.8% at 1 month to 68.8% at 6 months), while motor function improved gradually (from 50.0% to 69.4%). In an exploratory subgroup analysis, the short-duration group (n = 25) showed numerically higher rates than the long-duration group (n = 23) at 6 months (sensory: 80.0% vs. 56.5%, p = 0.08; motor: 85.0% vs. 50.0%, p = 0.034). However, after Bonferroni correction for multiple comparisons (corrected α = 0.0167), the motor improvement did not remain statistically significant. No severe adverse events occurred. The present study suggests that ultrasound-guided PRP injection appears safe and may be associated with functional improvement. The observed subgroup findings are hypothesis-generating and require confirmation in prospective randomized controlled trials.",
  "abstract_shown": true,
  "affiliations": [
    "Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China",
    "The Third Affiliated Hospital, Southern Medical University, Guangzhou, China",
    "Zhaoqing Hospital, Third Affiliated Hospital of Sun Yat-sen University, Zhaoqing, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Juanjuan He"
    },
    {
      "affs": [
        1
      ],
      "name": "Li Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Anna Tu"
    },
    {
      "affs": [
        0
      ],
      "name": "Na Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyan Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Lu"
    },
    {
      "affs": [
        2
      ],
      "name": "Ying Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaomei Wei"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/00wqg2wrsvvwh.bib",
  "cited_by": 0,
  "doi": "10.3389/ebm.2026.11091",
  "fulltext_url": "https://www.ebm-journal.org/articles/10.3389/ebm.2026.11091/full",
  "id": "00wqg2wrsvvwh",
  "issns": [
    "1535-3699",
    "1535-3702"
  ],
  "landing_url": "https://doi.org/10.3389/ebm.2026.11091",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2804|Nerve injury and regeneration"
    ]
  ],
  "openalex": "W7223694562",
  "pdf_url": "https://www.ebm-journal.org/journals/experimental-biology-and-medicine/articles/10.3389/ebm.2026.11091/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/00wqg2wrsvvwh.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:21:38Z",
      "native_id": "21a3bba67b554d2c91f981152ddd1604",
      "source": "doaj",
      "url": "https://doi.org/10.3389/ebm.2026.11091"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Nerve injury and regeneration",
      "subfield": "neuroscience"
    }
  ],
  "title": "Ultrasound-guided platelet-rich plasma injection for peripheral nerve injury: a retrospective exploratory study",
  "title_text": "Ultrasound-guided platelet-rich plasma injection for peripheral nerve injury: a retrospective exploratory study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:21:38Z",
  "url": "https://research.draconitic.com/paper/00wqg2wrsvvwh",
  "venue": "Experimental Biology and Medicine",
  "versions": []
}