{
  "abstract": "Background/Objectives: Long-term recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is heterogeneous, and early patient-reported outcomes (PROs) may provide clinically relevant information about later survivorship. We examined whether quality of life (QoL), fatigue, and early graft-versus-host disease (GVHD) were associated with PROs at 24 months after allo-HSCT. Methods: Adult allo-HSCT recipients were prospectively followed at six predefined timepoints up to 24 months. The primary early landmark was 6 months (T3), and the primary long-term outcome was 24-month (T6) QoL assessed using the Functional Assessment of Cancer Therapy—Bone Marrow Transplant (FACT-BMT). Fatigue was assessed using the Brief Fatigue Inventory (BFI) and Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT-F). Associations were examined using parsimonious regression models including early GVHD. Results: Twenty-eight participants had PRO data at both T3 and T6. Higher FACT-BMT at T3 was associated with higher FACT-BMT at T6 after adjustment for early GVHD (B = 1.077, 95% CI 1.019–1.135, p < 0.001). Early GVHD remained associated with lower T6 FACT-BMT (B = −6.133, 95% CI −9.373 to −2.893, p < 0.001). Higher BFI and lower FACIT-F at T3 were associated with poorer T6 QoL, while 6-month fatigue was also associated with corresponding 24-month fatigue outcomes. Among patients with GVHD, non-responders had less favorable 24-month fatigue outcomes than responders. Conclusions: PROs at 6 months were strongly associated with 24-month QoL and fatigue. The 6-month assessment may represent a clinically informative survivorship landmark, although larger multicenter studies are needed to confirm these associations.",
  "abstract_shown": true,
  "affiliations": [
    "Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 31-008 Krakow, Poland",
    "Department of Sport Didactics, Wroclaw University of Health and Sport Science, 51-612 Wroclaw, Poland",
    "Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, 31-008 Krakow, Poland",
    "Chair of Hematology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gabriela Lampart"
    },
    {
      "affs": [
        1
      ],
      "name": "Sebastian Klich",
      "orcid": "0000-0002-8182-2975"
    },
    {
      "affs": [
        2
      ],
      "name": "Agnieszka Gniadek",
      "orcid": "0000-0003-4179-6730"
    },
    {
      "affs": [
        3
      ],
      "name": "Beata Piątkowska-Jakubas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/01chwfk9cygzn.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18213542",
  "fulltext_url": null,
  "id": "01chwfk9cygzn",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/21/3542",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/01chwfk9cygzn.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:40Z",
      "native_id": "10.3390/cancers18213542",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/21/3542"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6694",
      "subfield": "oncology"
    }
  ],
  "title": "Early Patient-Reported Outcomes and Graft-Versus-Host Disease as Indicators of Long-Term Quality of Life and Fatigue After Allogeneic Hematopoietic Stem Cell Transplantation: A 24-Month Prospective Study",
  "title_text": "Early Patient-Reported Outcomes and Graft-Versus-Host Disease as Indicators of Long-Term Quality of Life and Fatigue After Allogeneic Hematopoietic Stem Cell Transplantation: A 24-Month Prospective Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:25Z",
  "url": "https://research.draconitic.com/paper/01chwfk9cygzn",
  "venue": "Cancers",
  "versions": []
}