{
  "abstract": "over 3-4 hours, twice weekly for 24 weeks. The primary endpoint was the change in the albumin-bilirubin (ALBI) score from baseline to week 24. Secondary endpoints included the Child-Pugh score, liver stiffness (vibration-controlled transient elastography and magnetic resonance elastography), serum fibrosis markers, and safety with specific monitoring of bleeding events.Patients Five adult males with hemophilia A (mean age 59.2 years) and HIV/HCV-associated cirrhosis, all with a sustained virologic response ≥48 months before enrolment.Results Four patients completed the treatment; one discontinued treatment at week 22 due to non-treatment-related pyogenic arthritis. ALBI score improved in all evaluable patients, with mean changes from baseline of -0.420±0.130 at week 24 and -0.318±0.302 at week 28, four weeks after treatment completion. The serum albumin levels increased during treatment and remained above baseline at week 28. No bleeding- or treatment-related serious adverse events occurred.Conclusion Prolonged foscenvivint was well tolerated and it was associated with an improved hepatic functional reserve during treatment in this biopsy-infeasible population. These findings are hypothesis-generating and suggest that noninvasive functional endpoints may be a feasible evaluation strategy, which requires confirmation in controlled studies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Kiminori Kimura"
    },
    {
      "name": "Akemi Ikoma"
    },
    {
      "name": "Noriyo Okamoto"
    },
    {
      "name": "Tomoyuki Endo"
    },
    {
      "name": "Ryotaro Sakamori"
    },
    {
      "name": "Mihoko Yotsumoto"
    },
    {
      "name": "Junji Imamura"
    },
    {
      "name": "Masamichi Kimura"
    },
    {
      "name": "Jun Imamura"
    },
    {
      "name": "Kunihisa Tsukada"
    },
    {
      "name": "Tetsuya Ishikawa"
    },
    {
      "name": "Tsunamasa Watanabe"
    },
    {
      "name": "Hiroshi Yotsuyanagi"
    },
    {
      "name": "Hiroyuki Gatanaga"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/020b2cbbzkq7j.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7831-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7831-26/_article",
  "id": "020b2cbbzkq7j",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7831-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2721|Liver Disease and Transplantation"
    ]
  ],
  "openalex": "W7224135303",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7831-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/020b2cbbzkq7j.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:08Z",
      "native_id": "10.2169/internalmedicine.7831-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7831-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver Disease and Transplantation",
      "subfield": "general"
    }
  ],
  "title": "Improving Hepatic Functional Reserve in Patients with Haemophilia and HIV/HCV-associated Cirrhosis: A Multicentre Prospective Study of Prolonged Foscenvivint Therapy",
  "title_text": "Improving Hepatic Functional Reserve in Patients with Haemophilia and HIV/HCV-associated Cirrhosis: A Multicentre Prospective Study of Prolonged Foscenvivint Therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:08Z",
  "url": "https://research.draconitic.com/paper/020b2cbbzkq7j",
  "venue": "Internal Medicine",
  "versions": []
}