{
  "abstract": "Previous studies have demonstrated that Telomerase Reverse Transcriptase (TERT) is localized inside mitochondria, where it associates with mitochondrial DNA (mtDNA), thereby influencing replication and transcription. Using a combination of quantitative fluorescence microscopy and biochemistry, we demonstrate that TERT binds indirectly to mtDNA through the interaction with mitochondrial transcription factor A (TFAM) to induce mitochondrial fragmentation. These findings reveal a novel mitochondrial interaction involving TERT and highlight a role for TERT and TFAM in the regulation of auto/mitophagy. This interaction is an important factor for mitochondrial function and contributes to the remodelling of mitochondrial respiratory capacity.",
  "abstract_shown": true,
  "affiliations": [
    "CNRS, Univ Rennes, IGDR"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "E. Rossi"
    },
    {
      "name": "J. Marinaccio"
    },
    {
      "name": "I. Festo"
    },
    {
      "name": "I. Udroiu"
    },
    {
      "name": "E. Micheli"
    },
    {
      "affs": [
        0
      ],
      "name": "G. Bertolin"
    },
    {
      "name": "A. Sgura"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/02bc94mx4ec1p.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.18.752609",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752609v1.full",
  "id": "02bc94mx4ec1p",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752609v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "1312|Mitochondrial Function and Pathology"
    ]
  ],
  "openalex": "W7214007302",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752609v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/02bc94mx4ec1p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:46Z",
      "native_id": "10.64898/2026.09.18.752609",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752609v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "TERT interacts with TFAM to activate mitochondrial fragmentation and auto/mitophagy",
  "title_text": "TERT interacts with TFAM to activate mitochondrial fragmentation and auto/mitophagy",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:46Z",
  "url": "https://research.draconitic.com/paper/02bc94mx4ec1p",
  "venue": "bioRxiv",
  "versions": []
}