{
  "abstract": "This study aimed to observe the effects of intraoperative goal-directed fluid therapy on postoperative recovery in older patients undergoing laparoscopic hernia or gallbladder surgery. A total of 60 older patients were randomly assigned to the control group (C group) and the goal- directed fluid therapy group (G group). The primary outcome was the plasma concentration of syndecan-1. The secondary outcomes were the plasma concentrations of tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1); mean arterial pressure; heart rate; regional cerebral oxygen saturation; intraoperative dopamine dosage; QoR-15 scale score; hematocrit; and postoperative adverse events. Compared with the C group, the G group showed decreased plasma concentrations of ICAM-1 at the end of surgery and 24 h after surgery (P = 0.010 and 0.005, respectively), decreased plasma concentrations of syndecan-1 at the end of surgery (P = 0.049), more significantly decreased plasma concentrations of VCAM-1 at the end of surgery and 24 h after surgery (P < 0.001 and P = 0.017, respectively), and decreased plasma concentrations of IL-1β at the end of surgery and 24 h after surgery (P = 0.009 and 0.008, respectively). The C group showed increased plasma concentration of TNF-α at the end of surgery and 24 h after surgery compared with those before surgery (P = 0.003 and 0.023, respectively). Compared with the C group, the QoR-15 scores were higher at 24, 48, and 72 h after surgery (P = 0.001, 0.001, and 0.005, respectively) in the treatment group. Intraoperative goal-directed fluid therapy in non-critically ill older patients may alleviate endothelial glycocalyx degradation with a lower incidence of adverse events. http://www.chictr.org.cn/, Chinese Clinical Trial Registry ChiCTR2500097999.",
  "abstract_shown": true,
  "affiliations": [
    "Affiliated Hospital, North Sichuan Medical College, Nanchong, China.",
    "Second Clinical Medical Institution of North Sichuan Medical College (Nanchong Central Hospital), Nanchong, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qinxian Wei"
    },
    {
      "affs": [
        0
      ],
      "name": "Man Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenji Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaxin Wan"
    },
    {
      "affs": [
        1
      ],
      "name": "Wuchang Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Fangjun Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/02gph07a5fwyh.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1922109",
  "fulltext_url": "https://europepmc.org/articles/PMC13713860",
  "id": "02gph07a5fwyh",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952895",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Trial"
    ],
    [
      "openalex",
      "2746|Hemodynamic Monitoring and Therapy"
    ]
  ],
  "openalex": "W7221776665",
  "pdf_url": "https://europepmc.org/articles/PMC13713860?pdf=render",
  "pmcid": "PMC13713860",
  "pmid": "42952895",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/02gph07a5fwyh.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42952895",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952895"
    },
    {
      "first_seen": "2026-11-01T12:21:27Z",
      "native_id": "PMC13713860",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1922109"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Hemodynamic Monitoring and Therapy",
      "subfield": "surgery"
    }
  ],
  "title": "The effect of goal-directed fluid therapy on endothelial glycocalyx and short-term postoperative recovery quality in older patients undergoing laparoscopic hernia or gallbladder surgery: a randomized controlled double-blind clinical study.",
  "title_text": "The effect of goal-directed fluid therapy on endothelial glycocalyx and short-term postoperative recovery quality in older patients undergoing laparoscopic hernia or gallbladder surgery: a randomized controlled double-blind clinical study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:27Z",
  "url": "https://research.draconitic.com/paper/02gph07a5fwyh",
  "venue": "Frontiers in medicine",
  "versions": []
}