{
  "abstract": "Circulating tumor DNA (ctDNA) is emerging as a key potential biomarker for post-diagnosis surveillance but it may also play a crucial role in the detection of pre-clinical cancer. Small-cell lung cancer (SCLC) is an excellent candidate for early detection given there are no successful therapeutic options for late-stage disease, and it displays almost universal inactivation of TP53. We assessed the presence of TP53 mutations in the cell-free DNA (cfDNA) extracted from the plasma of 51 SCLC cases and 123 non-cancer controls. We identified mutations using a pipeline specifically designed to accurately detect variants at very low fractions. We detected TP53 mutations in the cfDNA of 49% SCLC patients and 11.4% of non-cancer controls. When stratifying the 51 initial SCLC cases by stage, TP53 mutations were detected in the cfDNA of 35.7% early-stage and 54.1% late-stage SCLC patients. The results in the controls were further replicated in 10.8% of an independent series of 102 non-cancer controls. The detection of TP53 mutations in 11% of the 225 non-cancer controls suggests that somatic mutations in cfDNA among individuals without any cancer diagnosis is a common occurrence, and poses serious challenges for the development of ctDNA screening tests.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 25,
  "authors": [
    {
      "name": "Lynnette Fernandez-Cuesta"
    },
    {
      "name": "Sandra Perdomo"
    },
    {
      "name": "Patrice H Avogbe"
    },
    {
      "name": "Noemie Leblay"
    },
    {
      "name": "Tiffany M Delhomme"
    },
    {
      "name": "Valerie Gaborieau"
    },
    {
      "name": "Behnoush Abedi-Ardekani"
    },
    {
      "name": "Estelle Chanudet"
    },
    {
      "name": "Magali Olivier"
    },
    {
      "name": "David Zaridze"
    },
    {
      "name": "Anush Mukeria"
    },
    {
      "name": "Marta Vilensky"
    },
    {
      "name": "Ivana Holcatova"
    },
    {
      "name": "Jerry Polesel"
    },
    {
      "name": "Lorenzo Simonato"
    },
    {
      "name": "Cristina Canova"
    },
    {
      "name": "Pagona Lagiou"
    },
    {
      "name": "Christian Brambilla"
    },
    {
      "name": "Elisabeth Brambilla"
    },
    {
      "name": "Graham Byrnes"
    },
    {
      "name": "Ghislaine Scelo"
    },
    {
      "name": "Florence Le Calvez-Kelm"
    },
    {
      "name": "Matthieu Foll"
    },
    {
      "name": "James D Mckay"
    },
    {
      "name": "Paul Brennan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/02hrbrt2vb5jt.bib",
  "cited_by": 192,
  "doi": "10.1016/j.ebiom.2016.06.032",
  "fulltext_url": null,
  "id": "02hrbrt2vb5jt",
  "issns": [
    "2352-3964"
  ],
  "landing_url": "https://hal.science/hal-05842798v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1306|Cancer Genomics and Diagnostics"
    ]
  ],
  "openalex": "W2464329385",
  "pdf_url": "http://www.ebiomedicine.com/article/S2352396416302894/pdf",
  "pmcid": null,
  "pmid": "27377626",
  "published": "2026-10-28",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/02hrbrt2vb5jt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:03Z",
      "native_id": "hal-05842798",
      "source": "hal",
      "url": "https://hal.science/hal-05842798v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer Genomics and Diagnostics",
      "subfield": "oncology"
    }
  ],
  "title": "Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer",
  "title_text": "Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:03Z",
  "url": "https://research.draconitic.com/paper/02hrbrt2vb5jt",
  "venue": "EBioMedicine",
  "versions": []
}