{
  "abstract": "Even though binocular integration is a foremost example of integrative computations in the brain, it remains unknown how the visual cortex mediates it. Here, we investigated neuronal responses to binocular stimuli in layers 2/3 of mouse primary visual cortex (V1) and lateromedial (LM) area with in vivo two-photon imaging. We presented mice with three types of binocular stimuli: congruent gratings, orthogonal gratings and a flashing Mondrian pattern in binocular conflict with a grating. We looked for congruency-specific responses to the binocular stimuli, but found that most neurons responded homogeneously across stimulus types. Responses of cells with a strong monocular preference for the contralateral eye responded similarly to monocular and binocular stimulation, while responses of cells with a preference for ipsilateral stimuli showed a strong but nonspecific suppression to all binocular stimuli. Only cells without a strong monocular preference (i.e. binocular cells) exhibited linear integration of monocular responses to incongruent stimuli and binocular facilitation to congruent gratings. Responses to ipsilateral components of a binocular display were found to be poor predictors of binocular responses regardless of eye preference of individual cells. We conclude that most neuronal responses to binocular stimuli in mouse V1 & LM are uninformative about the congruency of the monocular components, with the exception of binocular cells which show either linear or supralinear integration.",
  "abstract_shown": true,
  "affiliations": [
    "University of Amsterdam"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "M. Bassler"
    },
    {
      "name": "G. Huis in't Veld"
    },
    {
      "name": "M. Suzuki"
    },
    {
      "affs": [
        0
      ],
      "name": "C. Pennartz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/02n0gj80cmvks.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.09.750336",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.09.750336v1.full",
  "id": "02n0gj80cmvks",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.09.750336v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2805|Visual perception and processing mechanisms"
    ]
  ],
  "openalex": "W7213331352",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.09.750336v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/02n0gj80cmvks.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:32Z",
      "native_id": "10.64898/2026.09.09.750336",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.09.750336v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Selective binocular integration in mouse visual cortex: binocular but not monocular neurons respond distinctly to congruent stimuli",
  "title_text": "Selective binocular integration in mouse visual cortex: binocular but not monocular neurons respond distinctly to congruent stimuli",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:32Z",
  "url": "https://research.draconitic.com/paper/02n0gj80cmvks",
  "venue": "bioRxiv",
  "versions": []
}