{
  "abstract": "Observational studies suggest an association between COVID-19 and acute myocardial infarction (AMI), however, whether this relationship is causal remains unclear. We conducted a multi-ancestry Mendelian randomization (MR) study across European, East Asian, South Asian, and African populations, evaluating three COVID-19 phenotypes: very severe COVID-19, hospitalized COVID-19, and general infection association with AMI. GWAS summary statistics were obtained from the COVID-19 Host Genetics Initiative Round 7 and UK Biobank/Biobank Japan for AMI. Inverse-variance weighted (IVW) MR was the primary method, with fixed-or random-effects models selected according to heterogeneity test. MR-Egger, weighted median and weighted mode were conducted as sensitivity analyses. In European ancestry, genetic liability to very severe COVID-19 and hospitalized COVID-19 was slightly inversely associated with AMI risk, but without statistical significances across sensitivity analyses. Hospitalized COVID-19 showed a suggestive but non-significant inverse association in South Asian ancestry. No significant associations were identified in East Asian or African ancestries. Our findings did not support a robust causal association between COVID-19 susceptibility or severity and AMI risk across ancestries, suggesting that the observed cardiovascular burden may be driven more by acute pathophysiological mechanisms than shared genetic architecture.",
  "abstract_shown": true,
  "affiliations": [
    "Brown University"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "K. Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Y. Ma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/02nan5jcybtx4.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.07.26364920",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.07.26364920v1.full",
  "id": "02nan5jcybtx4",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.07.26364920v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "cardiovascular medicine"
    ],
    [
      "openalex",
      "1311|Genetic Associations and Epidemiology"
    ]
  ],
  "openalex": "W7221092790",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.07.26364920v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/02nan5jcybtx4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:32Z",
      "native_id": "10.64898/2026.10.07.26364920",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.07.26364920v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:cardiovascular medicine",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Investigating the Causal Impact of COVID-19 on Acute Myocardial Infarction: A Multi-ancestry Mendelian Randomization Study",
  "title_text": "Investigating the Causal Impact of COVID-19 on Acute Myocardial Infarction: A Multi-ancestry Mendelian Randomization Study",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:32Z",
  "url": "https://research.draconitic.com/paper/02nan5jcybtx4",
  "venue": "medRxiv",
  "versions": []
}