{
  "abstract": "Organic electrochemical transistors (OECTs) offer unparalleled signal amplification and biocompatibility for biomolecular sensing. This review systematically explores OECT principles, sensing mechanisms, and architectures, focusing on advancements in metabolite detection. We highlight how innovations in polymer materials and gate functionalization enhance in vitro detection performance. Crucially, we evaluate the emerging transition toward in vivo applications, addressing the technological hurdles of signal fidelity and tissue-device interfaces in complex biological systems.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biotechnology and Food Engineering, Guangdong Technology Israel Institute of Technology (GTIIT), Shantou, China",
    "Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology (IIT), Haifa, Israel",
    "Guangdong Provincial Key Laboratory of Materials and Technologies for Energy Conversion, Guangdong Technion-Israel Institute of Technology (GTIIT), Shantou, China",
    "Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC, Australia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jintao Zheng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaohong Jiang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiacheng Yu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Runzhi Zhou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Haoyang Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Zheng Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Genquan Wu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Keying Guo",
      "orcid": "0000-0001-6383-6321"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/02nm6298nrn0b.bib",
  "cited_by": 5,
  "doi": "10.1038/s44328-026-00096-9",
  "fulltext_url": null,
  "id": "02nm6298nrn0b",
  "issns": [
    "3004-8656"
  ],
  "landing_url": "https://doi.org/10.1038/s44328-026-00096-9",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2507|Conducting polymers and applications"
    ]
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  "openalex": "W7162092827",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-22",
  "publisher": "Springer Science+Business Media",
  "ris": "https://research.draconitic.com/paper/02nm6298nrn0b.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:20Z",
      "native_id": "W7162092827",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s44328-026-00096-9"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2507|Conducting polymers and applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Organic electrochemical transistors for metabolite sensing across the transition from in vitro to in vivo",
  "title_text": "Organic electrochemical transistors for metabolite sensing across the transition from in vitro to in vivo",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T13:21:07Z",
  "url": "https://research.draconitic.com/paper/02nm6298nrn0b",
  "venue": "npj Biosensing",
  "versions": []
}