{
  "abstract": "Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are a promising cell-free therapeutic in preclinical models of tendon healing. However, clinical translation remains to be demonstrated. MSC-EVs modulate two critical and interlinked processes in tendon repair inflammation and angiogenesis primarily via delivery of bioactive cargo such as microRNAs and proteins. In inflammation, MSC-EVs promote the transition of macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, enhancing the resolution of inflammation. In angiogenesis, MSC-EVs facilitate endothelial cell proliferation and migration, promoting early vascularization followed by vascular regression during later healing. Recent advancements in MSC-EVs engineering and delivery systems have improved their therapeutic efficacy, yet further research is essential to elucidate their molecular mechanisms and achieve precise therapeutic outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biology, Faculty Mathematics and Natural Sciences, Universitas Indonesia, Jl. Prof. Dr. Mahar Mardjono, Depok 16424, Indonesia",
    "Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta 10430, Indonesia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Daffa Raditya Fernanda"
    },
    {
      "affs": [
        1
      ],
      "name": "Radiana Dhewayani Antarianto"
    },
    {
      "affs": [
        0
      ],
      "name": "Abinawanto Abinawanto"
    },
    {
      "affs": [
        0
      ],
      "name": "Retno Lestari"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0353d45rmsk78.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": null,
  "id": "0353d45rmsk78",
  "issns": [
    "2251-9637",
    "2251-9645"
  ],
  "landing_url": null,
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QD1-999"
    ],
    [
      "lcc",
      "QH426-470"
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  "openalex": null,
  "pdf_url": "http://ijmcmed.org/article-1-2633-en.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-01",
  "publisher": "Babol University of Medical Sciences",
  "ris": "https://research.draconitic.com/paper/0353d45rmsk78.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:48Z",
      "native_id": "80b4b6a5f3d44afeb4193eb6cbef2331",
      "source": "doaj",
      "url": null
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  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "lcc:QH426-470",
      "subfield": "genetics-genomics"
    },
    {
      "field": "chemistry",
      "origin": "lcc:QD1-999",
      "subfield": "general"
    }
  ],
  "title": "Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Tendon Regeneration: Insights into Inflammatory and Angiogenesis Modulation",
  "title_text": "Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Tendon Regeneration: Insights into Inflammatory and Angiogenesis Modulation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:48Z",
  "url": "https://research.draconitic.com/paper/0353d45rmsk78",
  "venue": "International Journal of Molecular and Cellular Medicine",
  "versions": []
}