{
  "abstract": "Background\n\nAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood, with methylphenidate hydrochloride (MPH) as its first-line pharmacotherapy. Though effective, MPH is associated with underrecognized gastrointestinal adverse events warranting further investigation. Recently, the gut microbiota has attracted attention for treating gastrointestinal distress, but research on its role in alleviating MPH-induced gastrointestinal reactions remains scarce.Methods\n\nHerein, Wistar-Kyoto rats (WKY) served as controls alongside spontaneously hypertensive rats (SHR) to explore MPH-induced gastrointestinal adverse drug reactions. The gastrointestinal phenotypes, colonic histopathological characteristics, and inflammatory factor levels were evaluated, and the gut microbiota profiles were analyzed via 16S rRNA gene sequencing. The protective effect of Parabacteroides distasonis (P. distasonis) was further verified by supplementing the treated rats with this strain.Results\n\nWe demonstrated MPH induced diarrhea and colonic inflammatory responses in rats. 16S rRNA gene amplicon sequencing revealed that MPH-treated rats had significantly decreased gut microbiota health index, increased dysbiosis index, and reduced P. distasonis abundance, suggesting MPH-induced gastrointestinal reactions may correlate closely with reduced P. distasonis. Further experiments confirmed that P. distasonis supplementation effectively alleviated diarrhea and colonic inflammatory responses in MPH-treated rats.Conclusions\n\nCollectively, this is the first study verifying that P. distasonis supplementation mitigates MPH-induced gastrointestinal adverse reactions, providing a novel intervention strategy to improve tolerance of ADHD pharmacotherapy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Occupational and Environmental Health, College of Public Health, Chongqing Medical University, No.1, Yixueyuan Road, Yuzhong District, Chongqing, 400016, People's Republic of China.",
    "Growth, Development and Mental Health Center of Children and Adolescents, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, People's Republic of China.",
    "Department of Toxicology, Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, School of Public Health, State Key Laboratory of Female Fertility Promotion, Peking University, Beijing, 100191, People's Republic of China.",
    "Department of Health Laboratory Technology, College of Public Health, Chongqing Medical University, No.1, Yixueyuan Road, Yuzhong District, Chongqing, 400016, People's Republic of China.",
    "Department of Health Laboratory Technology, College of Public Health, Chongqing Medical University, No.1, Yixueyuan Road, Yuzhong District, Chongqing, 400016, People's Republic of China. zhanghongyang@cqmu.edu.cn.",
    "Department of Occupational and Environmental Health, College of Public Health, Chongqing Medical University, No.1, Yixueyuan Road, Yuzhong District, Chongqing, 400016, People's Republic of China. chengzhichen@cqmu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinwen Yao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xia Gao"
    },
    {
      "affs": [
        1
      ],
      "name": "Lin Zhu"
    },
    {
      "affs": [
        2
      ],
      "name": "Linlin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qian Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Weijuan Liang"
    },
    {
      "affs": [
        3
      ],
      "name": "Huaili Feng"
    },
    {
      "affs": [
        3
      ],
      "name": "Ting You"
    },
    {
      "affs": [
        0
      ],
      "name": "Changli Wei"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuqi Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Hongyang Zhang",
      "orcid": "0009-0008-7018-3822"
    },
    {
      "affs": [
        5
      ],
      "name": "Chengzhi Chen",
      "orcid": "0000-0002-1087-4911"
    },
    {
      "name": "Li Chen",
      "orcid": "0000-0002-1766-5418"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/036acbjjk74v7.bib",
  "cited_by": 0,
  "doi": "10.1186/s12876-026-05079-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13682154",
  "id": "036acbjjk74v7",
  "issns": [
    "1471-230X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897488",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC799-869"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7170394092",
  "pdf_url": "https://europepmc.org/articles/PMC13682154?pdf=render",
  "pmcid": "PMC13682154",
  "pmid": "42897488",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/036acbjjk74v7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897488",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897488"
    },
    {
      "first_seen": "2026-10-30T13:46:06Z",
      "native_id": "c80bf81f7abb418cb5982f8a8b9f95b0",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12876-026-05079-8"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Parabacteroides distasonis ameliorates methylphenidate hydrochloride-induced colonic inflammatory responses and associated gastrointestinal distress.",
  "title_text": "Parabacteroides distasonis ameliorates methylphenidate hydrochloride-induced colonic inflammatory responses and associated gastrointestinal distress.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:06Z",
  "url": "https://research.draconitic.com/paper/036acbjjk74v7",
  "venue": "BMC gastroenterology",
  "versions": []
}