{
  "abstract": "Background\n\nPhotobiomodulation has gained considerable attention for its potential in various dermatological applications. We assessed the anti-aging effects of a home-use face-fit mask combining 630 and 850 nm light-emitting diodes (LEDs) and an anti-aging cream in ex vivo and prospective exploratory clinical studies. Both products are commercially available.Methods\n\nSkin samples from six women aged 39─55 years were either left untreated or received topical treatments for 7 days: LED irradiation (7-minute sessions) or cream (2 mg/cm²), or both. In the clinical study, women aged 49─65 years (n = 50) applied the cream daily to the face and neck for 56 days and used the mask 3─4 times per week.Results\n\nCompared to untreated skin samples, the combination of LEDs and cream increased the expression of elastin (+29.6%) and collagen 1 (+7.6%) (p< 0.05 for both). The expression of elastin also increased following treatment with the LEDs alone (+26.1%; p< 0.05). the effect of LEDs and cream combined treatment was demonstrated on collagen 1 expression, with a similar trend observed for elastin expression. In the clinical study, investigator-assessed clinical scores showed significant progressive improvements from baseline, reaching +57.1% for skin radiance, -39.4% for pore dilatation, and -24.2% for crow's feet wrinkle depth at Day 56 (p< 0.0001 for all). Participants also perceived significantly improved skin radiance and smoothing of face and neck wrinkles throughout the study.Conclusion\n\nThe LED mask and the anti-aging cream led to visible and clinically measurable skin signs of ageing reduction versus baseline. The increase in collagen I and elastin expression observed in the ex vivo study could contribute to the visible reduction in signs of aging demonstrated in the clinical study.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratoires, Pontoise, France.",
    "Gredeco, Paris, France."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Aurore Bellanger"
    },
    {
      "affs": [
        0
      ],
      "name": "Christelle Guéré"
    },
    {
      "affs": [
        1
      ],
      "name": "Sylvie Boisnic"
    },
    {
      "affs": [
        0
      ],
      "name": "Dorothée Godet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/03ge0sded7y4a.bib",
  "cited_by": 0,
  "doi": "10.1111/srt.70395",
  "fulltext_url": "https://europepmc.org/articles/PMC13695028",
  "id": "03ge0sded7y4a",
  "issns": [
    "0909-752X",
    "1600-0846"
  ],
  "landing_url": "https://europepmc.org/article/MED/42920345",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Dermatologic Treatments and Research"
    ]
  ],
  "openalex": "W7223464225",
  "pdf_url": "https://europepmc.org/articles/PMC13695028?pdf=render",
  "pmcid": "PMC13695028",
  "pmid": "42920345",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/03ge0sded7y4a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42920345",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42920345"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Dermatologic Treatments and Research",
      "subfield": "general"
    }
  ],
  "title": "Anti-Aging Efficacy of a Home-use red and Infrared Light-Emitting Diode Mask and a Cream: Ex Vivo and Clinical Evaluations in Women With Mature Skin.",
  "title_text": "Anti-Aging Efficacy of a Home-use red and Infrared Light-Emitting Diode Mask and a Cream: Ex Vivo and Clinical Evaluations in Women With Mature Skin.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/03ge0sded7y4a",
  "venue": "Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)",
  "versions": []
}