{
  "abstract": "Study Design: Prospective cohort.\n\nObjective: The primary objective was to describe bowel and bladder (BB) function by nerve root sacrifice following a Sacrectomy. Secondary objectives were to compare patient reported outcomes (PROs) based on BB function at 12 months, and to assess surgeon–patient reported BB function concordance.\n\nMethods: Data from AO Spine Knowledge Forum Tumor Primary Tumor Research and Outcomes Network (PTRON) registry included patients who underwent a sacrectomy (S1–S5) for a primary bone tumor, with at least one PRO reported at baseline and 12 months. BB function was recorded at baseline and 12 months. PROs included EQ-5D, SOSGOQv2.0, SF-36, leg/back NRS, ECOG.\n\nResults: Eighty-one patients were included. Bilateral S1–S2 sacrifice was associated with complete BB dysfunction; preservation of at least one S3 root was associated with preserved BB function in more than half of cases. Distal S4–S5 resections often preserved function, but about one-third had BB dysfunction. Agreement between surgeon–patient reported BB function was moderate (κ 0.39–0.45). At 12 months, patients with preserved BB function reported higher EQ-5D (0.70 vs 0.60, p=0.025) and SOSGOQv2.0 (83.5 vs 67.5, p=0.031), better ECOG (p= 0.028) and lower leg pain (0.5 vs 4.5, p=0.013).\n\nConclusion: A substantial proportion of patients experience BB dysfunction after sacrectomy, particularly with more cranial resections. This dysfunction aligned with worse PROs, greater pain, and poorer performance status. Agreement between surgeon- and patient-reported BB outcomes was moderate, emphasizing the importance of incorporating patient-reported measures into follow-up and counseling.",
  "abstract_shown": true,
  "affiliations": [
    "Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedics Surgery, University of British Columbia, Vancouver, BC, Canada",
    "Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, University of Texas, Houston, TX, USA",
    "Department of Spinal Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK",
    "Department of Neurosurgery, Brown University, Warren Alpert School of Medicine, Providence, RI, USA",
    "National Center for Spinal Disorders, Buda Health Center, Budapest, Hungary",
    "Department of Orthopaedics, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy",
    "Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy",
    "Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy",
    "Toronto Western Hospital, University of Toronto, ON, Canada",
    "Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA",
    "University Comprehensive Spine Center, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany",
    "Department of Biomedical Sciences for Health, University of Milan, Milan, Italy",
    "Department of Spine Surgery, IRCCS Galeazzi-Sant’Ambrogio Hospital, Milan, Italy",
    "Post Graduate Program of Orthopedics, University of Bologna, Bologna, Italy",
    "Department of Neurosurgery, University of California, San Francisco, CA, USA",
    "Department of Othopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA",
    "Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA",
    "Department of Neurosurgery, Spine Division, Duke University, Durham, NC, USA",
    "Department of Spine Surgery, University Hospital of Basel, Basel, Switzerland",
    "Department of Neurosurgery, New York University Langone Health, New York, NY, USA",
    "Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 22,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Taryn E. Ludwig",
      "orcid": "0000-0003-2791-9976"
    },
    {
      "affs": [
        1
      ],
      "name": "Laurence D. Rhines",
      "orcid": "0000-0002-8474-1521"
    },
    {
      "affs": [
        2
      ],
      "name": "Jeremy Reynolds"
    },
    {
      "affs": [
        3
      ],
      "name": "Ziya L. Gokaslan"
    },
    {
      "affs": [
        4
      ],
      "name": "Aron Lazary",
      "orcid": "0000-0002-0157-719X"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicolas Dea"
    },
    {
      "affs": [
        0
      ],
      "name": "Charles G. Fisher"
    },
    {
      "affs": [
        5
      ],
      "name": "Alessandro Luzzati"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Alessandro Gasbarrini"
    },
    {
      "affs": [
        8
      ],
      "name": "Y. Raja Rampersaud"
    },
    {
      "affs": [
        9
      ],
      "name": "Michelle J. Clarke"
    },
    {
      "affs": [
        10
      ],
      "name": "Alexander C. Disch"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Riccardo Cecchinato"
    },
    {
      "affs": [
        13
      ],
      "name": "Stefano Boriani"
    },
    {
      "affs": [
        14
      ],
      "name": "Praveen V. Mummaneni"
    },
    {
      "affs": [
        15
      ],
      "name": "Daniel G. Tobert"
    },
    {
      "affs": [
        16
      ],
      "name": "Ori Barzilai"
    },
    {
      "affs": [
        17
      ],
      "name": "C. Rory Goodwin",
      "orcid": "0000-0002-6540-2751"
    },
    {
      "affs": [
        18
      ],
      "name": "Cordula Netzer",
      "orcid": "0000-0001-7381-373X"
    },
    {
      "affs": [
        19
      ],
      "name": "Ilya Laufer"
    },
    {
      "affs": [
        20
      ],
      "name": "Jorrit-Jan Verlaan"
    },
    {
      "affs": [
        0
      ],
      "name": "Raphaële Charest-Morin",
      "orcid": "0000-0002-7689-1087"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/03n5hyn90jz6e.bib",
  "cited_by": 0,
  "doi": "10.1177/21925682261505882",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735763/",
  "id": "03n5hyn90jz6e",
  "issns": [
    "2192-5682",
    "2192-5690"
  ],
  "landing_url": "https://doi.org/10.1177/21925682261505882",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2730|Sarcoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7225264954",
  "pdf_url": null,
  "pmcid": "PMC13735763",
  "pmid": "42981593",
  "published": "2026-11-04",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/03n5hyn90jz6e.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:23Z",
      "native_id": "PMC13735763",
      "source": "pmc",
      "url": "https://doi.org/10.1177/21925682261505882"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Sarcoma Diagnosis and Treatment",
      "subfield": "oncology"
    }
  ],
  "title": "Bowel and Bladder Dysfunction and Patient-Reported Outcomes in Patients Undergoing a Sacrectomy for a Primary Bone Tumor an Observational Study From the Primary Tumor Research and Outcomes Network (PTRON)",
  "title_text": "Bowel and Bladder Dysfunction and Patient-Reported Outcomes in Patients Undergoing a Sacrectomy for a Primary Bone Tumor an Observational Study From the Primary Tumor Research and Outcomes Network (PTRON)",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:23Z",
  "url": "https://research.draconitic.com/paper/03n5hyn90jz6e",
  "venue": "Global Spine Journal",
  "versions": []
}