{ "abstract": "Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis. Computed tomography perfusion (CTP) can quantify tumor hemodynamic parameters. Dual-energy computed tomography (DECT) can quantify iodine concentration and may provide perfusion-related information. This study aimed to establish the relationship strength between DECT-derived iodine values and CTP-based parameters in PDAC. This study aimed to establish the relationship strength between DECT derived iodine values and CTP based parameters in PDAC. A total of 47 patients having histologically proven PDAC were enrolled in this study. These patients underwent multi-phase DECT scanning and concurrent dynamic CTP using a single source, fast kVp switching CT scanner. The DECT derived parameters and CTP derived parameters of pancreatic tumor and tumor-free pancreatic parenchyma were calculated, including iodine concentration (IC) and normalized iodine concentration (NIC) in the portal venous and delayed phases, as well as blood flow (BF), blood volume (BV), etc. Statistical different parameters between pancreatic tumor and tumor-free pancreatic parenchyma were analyzed by receiver-operating characteristic (ROC) curves. The diagnostic capability was determined by calculating the area under the curve (AUC). A paired t-test and Pearson correlation were used to evaluate the two techniques. For the tumor lesion, IC was 15.21±5.09 and 15.98±4.71 mg/mL in the portal venous and delayed phases, while NIC was 0.31±0.10 and 0.51±0.14. For the tumor-free pancreatic parenchyma, the corresponding values were 27.25±5.43 mg/mL and 21.67±5.23 mg/mL for IC, and 0.55±0.11 and 0.70±0.18 for NIC, respectively. For the tumor lesion, BF and BV were 30.25±11.80 mL/100 g/min and 3.53±2.42 mL/100 g, respectively. For the tumor-free pancreatic parenchyma, BF and BV were 109.74±56.79 mL/100 g/min and 10.77±2.84 mL/100 g, respectively. BF, BV, mean slope of increase (MSI), positive enhancement integral (PEI) and IC in portal venous phase (IC_VP), NIC in portal venous phase (NIC_VP) showed very high diagnostic accuracy (AUC: 0.957-0.981), while IC in delayed phase (IC_DP) and NIC in delayed phase (NIC_DP) demonstrated moderate accuracy. The IC_VP of the tumor lesions showed a moderate positive correlation with BF and BV (r=0.653 and r=0.461, respectively; both P<0.001). The NIC_VP of the tumor lesions also showed a moderate positive correlation with BF and BV (r=0.645 and r=0.491, respectively; both P<0.001). In PDAC tumor lesions, DECT derived IC and NIC both show moderate positive correlations with BF and BV, with stronger correlations observed for BF, enabling DECT to evaluate both morphological and perfusion changes.", "abstract_shown": true, "affiliations": [ "Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.", "Department of Biliary and Pancreatic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.", "Department of Radiology, Hefei First People's Hospital, Hefei, China.", "CT Imaging Research Center, GE HealthCare China, Shanghai, China." ], "article_type": "research article", "arxiv": null, "author_total": 14, "authors": [ { "affs": [ 0 ], "name": "Shuai Ming", "orcid": "0000-0003-0016-7209" }, { "affs": [ 0 ], "name": "Yuanyuan Ruan" }, { "affs": [ 0 ], "name": "Peng Cheng" }, { "affs": [ 0 ], "name": "Dan Shi" }, { "affs": [ 0 ], "name": "Bin Wang" }, { "affs": [ 0 ], "name": "Jingyu Li" }, { "affs": [ 0 ], "name": "Minmin Du" }, { "affs": [ 0 ], "name": "Yiwen Zhang" }, { "affs": [ 0 ], "name": "Yuhang Yang" }, { "affs": [ 0 ], "name": "Hongji Zhu", "orcid": "0009-0001-7956-7979" }, { "affs": [ 1 ], "name": "Chenglin Zhu" }, { "affs": [ 2 ], "name": "Xiaoyong Zhang" }, { "affs": [ 3 ], "name": "Aiyun Sun" }, { "affs": [ 0 ], "name": "Wei Wei", "orcid": "0000-0003-4097-1592" } ], "bibtex": "https://research.draconitic.com/paper/03tqwsra3pz6m.bib", "cited_by": 0, "doi": "10.21037/jgo-2026-0553", "fulltext_url": "https://europepmc.org/articles/PMC13740546", "id": "03tqwsra3pz6m", "issns": [ "2078-6891", "2219-679X" ], "landing_url": "https://europepmc.org/article/MED/42996559", "language": "eng", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "2204|Advanced X-ray and CT Imaging" ] ], "openalex": "W7224100906", "pdf_url": "https://europepmc.org/articles/PMC13740546?pdf=render", "pmcid": "PMC13740546", "pmid": "42996559", "published": "2026-09-28", "publisher": null, "ris": "https://research.draconitic.com/paper/03tqwsra3pz6m.ris", "sources": [ { "first_seen": "2026-11-09T15:20:41Z", "native_id": "MED:42996559", "source": "europepmc", "url": "https://europepmc.org/article/MED/42996559" } ], "subjects": [ { "field": "medicine", "origin": "journal-openalex:2730|Gastric Cancer Management and Outcomes", "subfield": "oncology" } ], "title": "Dual-energy computed tomography as an alternative to computed tomography perfusion for assessment of pancreatic ductal adenocarcinoma.", "title_text": "Dual-energy computed tomography as an alternative to computed tomography perfusion for assessment of pancreatic ductal adenocarcinoma.", "type": "peer-reviewed", "updated_at": "2026-11-09T15:20:41Z", "url": "https://research.draconitic.com/paper/03tqwsra3pz6m", "venue": "Journal of gastrointestinal oncology", "versions": [] }