{
  "abstract": "Dry eye represents an increasingly prominent public health burden in modern society. However, the limitations of currently available treatment options have necessitated the pursuit of new therapies. Here we report the repurposing of everolimus (Evero), an mTOR inhibitor with poor aqueous solubility, for dry eye management. Meanwhile, a tear-triggered in situ gelling system (EveroGel) based on the design principle of enhanced solubilization and retention was developed for topical administration of Evero. It was showed that the proposed formulation strategy can facilitate tissue permeation and decrease lacrimal clearance. Evero mitigated the severity of dry eye in a scopolamine-induced mouse model regarding corneal fluorescein, TUNEL, K10 immunofluorescent and conjunctival PAS staining. However, more favorable outcomes were obtained with EveroGel. All excipients present in EveroGel are FDA-approved. Hence, no toxic effects have been observed in the in vivo biocompatibility study. Our work demonstrates the therapeutic potential of rationally engineered ophthalmic formulations of Evero for treating dry eye.",
  "abstract_shown": true,
  "affiliations": [
    "National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China",
    "State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China",
    "Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233099, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jing-jie Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Si-yu Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xin-xin Liu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hao Zhou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Si-hang Song"
    },
    {
      "affs": [
        2
      ],
      "name": "Chen-chen Zhu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiu-juan Lv"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kai-hui Nan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/04854y8fgfpzd.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103782",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733472/",
  "id": "04854y8fgfpzd",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://doi.org/10.1016/j.mtbio.2026.103782",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full Length Article"
    ],
    [
      "openalex",
      "3003|Advanced Drug Delivery Systems"
    ]
  ],
  "openalex": "W7223696229",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2590006426010276/pdf",
  "pmcid": "PMC13733472",
  "pmid": "42985178",
  "published": "2026-10-26",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/04854y8fgfpzd.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:14Z",
      "native_id": "PMC13733472",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.mtbio.2026.103782"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Advanced Drug Delivery Systems",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Ocular delivery of repurposed everolimus against dry eye with a tear-triggered in situ hydrogel based on enhanced solubilization and retention",
  "title_text": "Ocular delivery of repurposed everolimus against dry eye with a tear-triggered in situ hydrogel based on enhanced solubilization and retention",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:14Z",
  "url": "https://research.draconitic.com/paper/04854y8fgfpzd",
  "venue": "Materials Today Bio",
  "versions": []
}