{
  "abstract": "Published artificial intelligence for keratoconus is unproven in fellow eyes that topography and tomography call normal, the eyes where surgical decisions are made, although it reports near-perfect accuracy for early disease. In a registered systematic review of 573 studies (PROSPERO CRD420261441197), none of 2,035 claim-by-stratum units from 212 adjudicated studies established discrimination in these eyes. Most units (90.0%) answered a different question, never constructed the target population or certified its normality; external validation did not test label generation, and five systematic reviews did not assess it. In a public cohort, a frozen score yielded an area under the receiver operating characteristic curve of 0.996 against a same-eye index label and 0.549 against a contralateral proxy; its inputs reconstructed the label-generating index (r = 0.991), so accuracy there measured agreement with the index. Anchor-gap evaluation measures accuracy in these eyes against the contralateral clinical diagnosis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "H. Jiang"
    },
    {
      "name": "F. Gao"
    },
    {
      "name": "Y. Jie"
    },
    {
      "name": "L. Yang"
    },
    {
      "name": "Y. Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Y. Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/04pxdg7vmgtsr.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.29.26364068",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.29.26364068v1.full",
  "id": "04pxdg7vmgtsr",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.29.26364068v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "ophthalmology"
    ],
    [
      "openalex",
      "2741|Corneal surgery and disorders"
    ]
  ],
  "openalex": "W7215727323",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.29.26364068v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/04pxdg7vmgtsr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:56Z",
      "native_id": "10.64898/2026.09.29.26364068",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.29.26364068v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Corneal surgery and disorders",
      "subfield": "imaging"
    }
  ],
  "title": "Systematic review finds keratoconus AI unproven in fellow eyes with normal topography and tomography",
  "title_text": "Systematic review finds keratoconus AI unproven in fellow eyes with normal topography and tomography",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:56Z",
  "url": "https://research.draconitic.com/paper/04pxdg7vmgtsr",
  "venue": "medRxiv",
  "versions": []
}