{
  "abstract": "Only older mosquitoes transmit malaria, so how warming changes mosquito ageing matters for disease. Warmer temperatures are known to make mosquitoes age faster, but 'faster' can mean two different things: the ageing clock ticks more quickly, or it is simply set forward. We distinguished these by reanalysing 115 whole-body RNA-sequencing libraries from female Anopheles gambiae kept at 27, 30 or 32 {degrees}C and sampled 1-15 days after emergence. A transcriptomic clock trained on 27 {degrees}C mosquitoes (error {+/-}0.9 days) read 32 {degrees}C mosquitoes as 2.4 days older (95% CI 1.9-2.9) and 30 {degrees}C mosquitoes as 1.1 days older. The gap opened by day 5 and then stopped growing: between days 5 and 15, warmth added 0.01 extra days per day (95% CI -0.16 to 0.19), well below the 0.29-0.45 expected if the clock ran faster. Genome-wide, warmth advanced genes that change late in life, notably melanisation and digestive genes, but moved early-maturation genes the opposite way. Many responses bent at 30 {degrees}C, and immune genes held until 30 {degrees}C before falling. Warmth therefore shifts mosquitoes to an older transcriptional state without accelerating its pace.",
  "abstract_shown": true,
  "affiliations": [
    "Visva-Bharati"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "K. Sinha"
    },
    {
      "name": "N. Ghosh"
    },
    {
      "name": "S. Banerjee"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/04q4w2cpme3w8.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.13.758761",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758761v1.full",
  "id": "04q4w2cpme3w8",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758761v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7211865443",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758761v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/04q4w2cpme3w8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:21Z",
      "native_id": "10.64898/2026.10.13.758761",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.13.758761v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "Warmth shifts rather than speeds transcriptomic ageing in the malaria mosquito Anopheles gambiae",
  "title_text": "Warmth shifts rather than speeds transcriptomic ageing in the malaria mosquito Anopheles gambiae",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:21Z",
  "url": "https://research.draconitic.com/paper/04q4w2cpme3w8",
  "venue": "bioRxiv",
  "versions": []
}