{
  "abstract": "Background\n\nMicroRNAs (miRNAs) may participate in biological pathways relevant to emphysema, but their associations with quantitative emphysema in human lung tissue remain uncertain.Methods\n\nWe analyzed lung tissue miRNA expression and clinical phenotypes from 117 patients with COPD/emphysema in GSE201121. After expression filtering, 839 miRNA loci were evaluated for association with percent emphysema (quantitative CT-derived percent low-attenuation area below -950 HU) using linear regression adjusted for age and sex with HC3 heteroskedasticity-robust standard errors. Multiple testing was controlled using the Benjamini-Hochberg false discovery rate (BH-FDR). Significant loci were collapsed to unique mature miRNAs. Secondary analyses examined associations with FEV₁ % predicted, FEV₁/FVC, and DLCO. Sensitivity analyses excluded influential observations, used log-transformed percent emphysema, and evaluated former smokers with adjustment for pack-years. Experimentally validated miRNA-target interactions were queried using multiMiR, followed by Gene Ontology Biological Process enrichment.Results\n\nFourteen miRNAs were associated with percent emphysema at BH-FDR <0.05. Eight miRNAs showed positive associations with emphysema (miR-144-5p, miR-190a, miR-20b-5p, miR-451a, miR-3912, miR-15a-5p, miR-202-5p, and miR-4497), whereas six showed negative associations (miR-489, miR-181b-5p, miR-378a-5p, miR-3614-5p, miR-197-3p, and miR-877-3p). Associations with lung function were consistent with the emphysema findings across all 14 miRNAs. After phenotype-specific BH-FDR correction, 12 miRNAs were associated with FEV₁ % predicted, 12 with FEV₁/FVC, and 8 with DLCO. All 14 associations retained their direction and significance across sensitivity analyses. Enrichment analyses of experimentally supported targets identified processes related to miRNA regulation, apoptosis, hypoxia/oxygen responses, cell-cycle regulation, and vasculature development.Conclusion\n\nLung-tissue expression of 14 mature miRNAs was associated with percent emphysema and lung function in COPD, while target-enrichment findings based on experimentally supported interaction databases were exploratory and require independent and functional validation.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Pulmonology, Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Republic of Korea.",
    "Department of Laboratory Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Taeyun Kim",
      "orcid": "0000-0001-7786-5051"
    },
    {
      "affs": [
        1
      ],
      "name": "Hyunji Choi"
    },
    {
      "affs": [
        0
      ],
      "name": "Chul-Ho Oak"
    },
    {
      "affs": [
        0
      ],
      "name": "Taehwa Kim",
      "orcid": "0000-0003-3722-0261"
    },
    {
      "affs": [
        0
      ],
      "name": "Tae Won Jang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0524hkrhv3dq2.bib",
  "cited_by": 0,
  "doi": "10.2147/copd.s653811",
  "fulltext_url": "https://europepmc.org/articles/PMC13712142",
  "id": "0524hkrhv3dq2",
  "issns": [
    "1176-9106",
    "1178-2005"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948330",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2740|Chronic Obstructive Pulmonary Disease (COPD) Research"
    ]
  ],
  "openalex": "W7223345379",
  "pdf_url": "https://europepmc.org/articles/PMC13712142?pdf=render",
  "pmcid": "PMC13712142",
  "pmid": "42948330",
  "published": "2026-10-23",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/0524hkrhv3dq2.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42948330",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948330"
    },
    {
      "first_seen": "2026-10-31T12:22:47Z",
      "native_id": "PMC13712142",
      "source": "pmc",
      "url": "https://doi.org/10.2147/copd.s653811"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Chronic Obstructive Pulmonary Disease (COPD) Research",
      "subfield": "general"
    }
  ],
  "title": "Association of Lung Tissue MicroRNA Expression with Quantitative Emphysema in COPD: An Exploratory Transcriptomic Analysis.",
  "title_text": "Association of Lung Tissue MicroRNA Expression with Quantitative Emphysema in COPD: An Exploratory Transcriptomic Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:47Z",
  "url": "https://research.draconitic.com/paper/0524hkrhv3dq2",
  "venue": "International journal of chronic obstructive pulmonary disease",
  "versions": []
}