{
  "abstract": "MicroRNAs (miRNAs) are a class of small non-coding RNAs that significantly impact skin rejuvenation via gene regulation that is involved in mechanisms such as regeneration, wound repair, and aging. By potentially shifting pathways modulating inflammation, cell proliferation, and extracellular matrix remodeling, they can be considered as an effective anti-aging intervention candidate. Such molecular mechanisms of miRNAs in cutaneous homeostasis of fibroblast activity, keratinocyte differentiation, and collagen synthesis are provided in the current review. Representative miRNAs such as miRNA-124, miRNA-377, miRNA-34 family, and miRNA-29 family, miRNA-302b-3p, miRNA-361-5p, miRNA-146a, miRNA-21, miRNA-181-a, miRNA155 demonstrate distinct roles in regulating wound healing, inflammatory resolution, maintaining the extracellular matrix, and handling oxidative stress. This review highlights current knowledge of miRNA-mediated regulation in skin regeneration and aging and synthesizes recent findings on their individual functions in these biological processes. It also emphasizes the potential of miRNA-based interventions as a next generation approach to skin rejuvenation, while addressing existing challenges that must be resolved before these strategies can be translated into clinical applications.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Advanced Biological Sciences and Technologies, University of Science and Culture, Tehran, Iran",
    "Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran",
    "Skin and Stem Cell Research Center, Tehran University of Medical Science, Iran"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hanieh Azizi"
    },
    {
      "affs": [
        1
      ],
      "name": "Reza Moghadasali"
    },
    {
      "affs": [
        2
      ],
      "name": "Amir Mohammad Amirkhani"
    },
    {
      "affs": [
        2
      ],
      "name": "Ehsan Taghiabadi"
    },
    {
      "affs": [
        2
      ],
      "name": "Mohammad Ali Nilforoushzadeh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/05chgz7n8mdc2.bib",
  "cited_by": 0,
  "doi": "10.15698/cst2026.10.322",
  "fulltext_url": "http://cell-stress.com/researcharticles/2026a-azizi-cell-stress",
  "id": "05chgz7n8mdc2",
  "issns": [
    "2523-0204"
  ],
  "landing_url": "https://doi.org/10.15698/cst2026.10.322",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Shared Science Publishers OG",
  "ris": "https://research.draconitic.com/paper/05chgz7n8mdc2.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T14:21:07Z",
      "native_id": "06755468a40d4076820794c4d8aaf57c",
      "source": "doaj",
      "url": "https://doi.org/10.15698/cst2026.10.322"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "lcc:QH301-705.5",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "lcc:R",
      "subfield": "general"
    }
  ],
  "title": "MicroRNA as key players in skin regeneration and anti-aging pathways",
  "title_text": "MicroRNA as key players in skin regeneration and anti-aging pathways",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T14:20:21Z",
  "url": "https://research.draconitic.com/paper/05chgz7n8mdc2",
  "venue": "Cell Stress",
  "versions": []
}