{
  "abstract": "Brain-computer interfaces (BCIs) have made significant progress in fields such as neurorehabilitation, motor reconstruction, and alternative communication by capturing, decoding, and providing feedback on brain activity. In contrast, the application of BCI in oncology has a relatively late start, but its development path has gradually become clearer in recent years. On the one hand, brain-signal interfaces based on neural feedback and closed-loop regulation have begun to be used for interventions targeting cancer-related neurological symptoms, particularly cancer pain and chemotherapy-induced peripheral neuropathy (CIPN), suggesting that supportive cancer care is shifting from empirical symptomatic management toward quantifiable, feedback-based, and adjustable neural state management. On the other hand, in the field of brain tumors, ECoG recording, high-density neural recording, and real-time decoding are providing complementary information on abnormal peritumoral networks and tumor-associated epilepsy within established function-guided surgical workflows. These recording and decision-support approaches are related to BCI engineering but are not automatically BCIs or substitutes for direct electrical stimulation mapping. More importantly, advances in tumor neuroscience suggest that neural activity not only reflects the disruption of host brain tissue by the tumor but may also participate in glioma growth and invasion through circuit remodeling and microenvironmental changes. This article provides a review of the fundamentals of BCI technology, the management of cancer-related symptoms, brain-computer interfaces in brain tumors, tumor neuroscience, tumor-neural-immune interactions, and their translational challenges. Current evidence suggests that the significance of BCI in oncology is no longer limited to assistive devices but is evolving into a novel engineering platform that integrates symptom control, surgical decision-making, and research into disease mechanisms.",
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  "affiliations": [
    "Central Hospital, Tianjin University",
    "Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases",
    "Tianjin Artificial Cell Engineering Technology Research Center",
    "Tianjin Institute of Hepatobiliary Disease",
    "Tianjin Institute of Geriatrics, Tianjin Third Central Hospital Branch",
    "Department of Oncology, Central Hospital, Tianjin University",
    "Department of Laboratory, Central Hospital, Tianjin University",
    "Department of General Surgery, Central Hospital, Tianjin University",
    "Medical School, Tianjin University",
    "Institute for Global Health Sciences, University of California, San Francisco",
    "Department of Physiology, University of California, San Francisco"
  ],
  "article_type": null,
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  "author_total": 13,
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      "name": "Jiaxin Li"
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      "name": "Hongsheng Guo"
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      "name": "Chenxuan Wu"
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      "name": "Ximo Wang"
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  ],
  "bibtex": "https://research.draconitic.com/paper/05hmht7tkfsca.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1953098",
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  "id": "05hmht7tkfsca",
  "issns": [
    "1664-3224"
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  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1953098/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1953098/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/05hmht7tkfsca.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1953098",
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|EEG and Brain-Computer Interfaces",
      "subfield": "neuroscience"
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  "title": "Research advances in brain-computer interfaces in oncology: from cancer pain management to neuroengineering for brain tumors and tumor-neural-immune interactions",
  "title_text": "Research advances in brain-computer interfaces in oncology: from cancer pain management to neuroengineering for brain tumors and tumor-neural-immune interactions",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:17Z",
  "url": "https://research.draconitic.com/paper/05hmht7tkfsca",
  "venue": "Frontiers in Immunology",
  "versions": []
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