{
  "abstract": "INTRODUCTION: Real‐world modifiers of lecanemab benefit in Alzheimer's disease (AD) remain elusive. We examined associations between caregiver positivity and longitudinal outcomes in AD.\n\nMETHODS: This seven‐center longitudinal study followed 127 biomarker‐supported AD patient–caregiver dyads over 18 months. Mixed‐effects, spline, and propensity‐score analyses evaluated continuous Positive Aspects of Caregiving (PAC) scores.\n\nRESULTS: Higher baseline PAC scale scores were associated with more favorable 18‐month outcomes in cognition (Mini‐Mental State Examination (MMSE): β = 0.42, 95% confidence interval [CI]: 0.24–0.59; p < 0.001), daily function (Alzheimer's Disease Cooperative Study–Activities of Daily Living [ADCS‐ADL]: β = 0.68, 95% CI: 0.42–0.93; p < 0.001), disease severity (Clinical Dementia Rating–Sum of Boxes [CDR‐SB]: β = −0.26, 95% CI: −0.37 to −0.14; P < 0.001), patient quality of life (Quality of Life in Alzheimer's Disease [QOL‐AD]: β = 0.53, 95% CI: 0.34–0.71; p < 0.001), and lower apathy ( β = −0.09, 95% CI: −0.16 to −0.03; p = 0.003); these associations remained significant after multiplicity correction (all q’s ≤ 0.004). Patient QOL‐AD showed the most consistent sensitivity‐analysis association. Apathy was associated with caregiver burden and caregiver quality of life, but mediation was not established.\n\nDISCUSSION: Caregiver positivity may stratify lecanemab efficacy in AD, supporting psychosocial assessment in personalized, caregiver‐inclusive management pathways.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases Huanhu Hospital Affiliated to Tianjin Medical University Tianjin China",
    "Department of Neurology The First Hospital of China Medical University Shenyang China",
    "Department of Neurology, Qinhuangdao Hospital of Dongfang Hospital Beijing University of Chinese Medicine (Qinhuangdao Hospital of Traditional Chinese Medicine) Qinhuangdao China",
    "Department of Neurology Cangzhou People's Hospital Cangzhou China",
    "Department of Neurology, The Sixth Clinical College of Changzhi Medical College Linfen Central Hospital Linfen China",
    "Department of Neurology The Second Affiliated Hospital of Xiamen Medical University Xiamen China",
    "Department of Neurology Yuncheng Central Hospital Yuncheng China",
    "Medical Department Eisai China Inc. Shanghai China",
    "Department of Acupuncture and Moxibustion Tianjin University of Traditional Chinese Medicine Tianjin China",
    "School of Nursing Tianjin Medical University Tianjin China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wenjing Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Huayan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yun Liang"
    },
    {
      "affs": [
        2
      ],
      "name": "Huai'an Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Jinhong Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Zhen Sun"
    },
    {
      "affs": [
        5
      ],
      "name": "Yehua Song"
    },
    {
      "affs": [
        6
      ],
      "name": "Min Fei"
    },
    {
      "affs": [
        0
      ],
      "name": "Hao Wu"
    },
    {
      "affs": [
        7
      ],
      "name": "Mo Jiang"
    },
    {
      "affs": [
        8
      ],
      "name": "Shiyv Fan"
    },
    {
      "affs": [
        9
      ],
      "name": "Chaohui Zhou"
    },
    {
      "affs": [
        9
      ],
      "name": "Yv Cao"
    },
    {
      "affs": [
        9
      ],
      "name": "Hui Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuai Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/05qetsfvhg5y8.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71894",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714101/",
  "id": "05qetsfvhg5y8",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://doi.org/10.1002/alz.71894",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
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      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
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  "openalex": "W7224102991",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.71894",
  "pmcid": "PMC13714101",
  "pmid": "42947278",
  "published": "2026-10-27",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/05qetsfvhg5y8.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:39Z",
      "native_id": "PMC13714101",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71894"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
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  ],
  "title": "Caregiver positivity as a psychosocial modifier of lecanemab‐related outcomes in Alzheimer's disease: A multicenter longitudinal study in China",
  "title_text": "Caregiver positivity as a psychosocial modifier of lecanemab‐related outcomes in Alzheimer's disease: A multicenter longitudinal study in China",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:39Z",
  "url": "https://research.draconitic.com/paper/05qetsfvhg5y8",
  "venue": "Alzheimer's & Dementia",
  "versions": []
}