{
  "abstract": "Objective\n\nIn this study, we aimed to explore the relationship between endothelial activation and stress index (EASIX) and the incidence of major adverse cardiovascular events (MACE) in acute myocardial infarction (AMI) patients.Method\n\nThis retrospective study was based on the clinical data of the AMI patients admitted in emergency department of Changsha Central Hospital from August 2020 to January 2023. Different models were constructed by multivariable regression analysis for investigating the relationship between EASIX index and MACE risk. Restricted cubic spline (RCS) analysis was utilized for further validating the potential nonlinear relationship. The receiver-operator characteristic (ROC) analysis of EASIX index for predicting MACE risk in AMI was done.Results\n\n805 AMI patients with 193 individuals in MACE group were included. After adjusting potential confounders, with per unit increasement in EASIX index, the risk of MACE increased by 16% (OR = 1.16, 95%CI: 1.04-1.29, p = 0.0054). The RCS showed the nonlinear relationship between EASIX index and the incidence of MACE was not significant. The predictive performances of EASIX index were showed as follow: an AUC of 0.687 (95%CI:0.642-0.732) and a cut-off value of 2.42.Conclusion\n\nA significant relationship between EASIX index and the incidence of MACE in AMI was identified.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Emergency Medicine, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.",
    "Sepsis Research Center of Hunan Provincial Geriatric Institute, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.",
    "Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.",
    "Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.",
    "Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China. doctordingning@sina.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yan Cao"
    },
    {
      "affs": [
        2
      ],
      "name": "Bowen Xiong",
      "orcid": "0009-0004-7610-5543"
    },
    {
      "affs": [
        3
      ],
      "name": "Tangyi Zeng"
    },
    {
      "affs": [
        2
      ],
      "name": "Liudang He"
    },
    {
      "affs": [
        2
      ],
      "name": "Yingjie Su"
    },
    {
      "affs": [
        4
      ],
      "name": "Ning Ding",
      "orcid": "0000-0001-7491-9157"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/05r186vzgtc5e.bib",
  "cited_by": 0,
  "doi": "10.1186/s12873-026-01682-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13726026",
  "id": "05r186vzgtc5e",
  "issns": [
    "1471-227X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972255",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2705|Acute Myocardial Infarction Research"
    ]
  ],
  "openalex": "W7172165024",
  "pdf_url": "https://europepmc.org/articles/PMC13726026?pdf=render",
  "pmcid": "PMC13726026",
  "pmid": "42972255",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/05r186vzgtc5e.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42972255",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972255"
    },
    {
      "first_seen": "2026-11-05T12:22:27Z",
      "native_id": "PMC13726026",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12873-026-01682-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "The relationship between endothelial activation and stress index (EASIX) and the incidence of major adverse cardiovascular events in acute myocardial infarction patients admitted in emergency department.",
  "title_text": "The relationship between endothelial activation and stress index (EASIX) and the incidence of major adverse cardiovascular events in acute myocardial infarction patients admitted in emergency department.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:04Z",
  "url": "https://research.draconitic.com/paper/05r186vzgtc5e",
  "venue": "BMC emergency medicine",
  "versions": []
}