{
  "abstract": "OBJECTIVE: To assess whether weight change during routine clinical care is associated with DAS28-CRP trajectories in rheumatoid arthritis (RA) with obesity. METHODS: ) were included. Regression-based percentage weight change over observed follow-up was estimated for each patient using all available weight measurements. Outcomes were repeated DAS28-CRP, DAS28-CRP components, remission (DAS28-CRP<2.6) and low disease activity (≤3.2). Mixed-effects models estimated weight change-by-time interactions with prespecified adjustment. Missing data were handled using multiple imputation. Sensitivity analyses included categorical weight-change modelling, a 6-month landmark design, and censoring at DMARD change. RESULTS: and obesity was class I in 76 (71.7%). The weight-change-by-time interaction for DAS28-CRP was close to null (-0.004 units/year per 5% weight change, 95% CI: -0.026 to 0.018). Weight change was not associated with changes over time in the odds of remission (interaction OR: 1.01 per 5%, 95% CI: 0.96 to 1.06) or low disease activity (interaction OR: 1.00 per 5%, 95% CI: 0.94 to 1.07), and no signal was observed for DAS28-CRP components.. Sensitivity analyses were consistent (weight loss≥5% vs. stable: +0.021 units/year, 95% CI: -0.076 to 0.119; weight gain≥5% vs. stable: -0.003 units/year, 95% CI: -0.158 to 0.153). CONCLUSIONS: In RA with predominantly class I obesity, we did not observe a clear association between routine clinical care weight change and improved inflammatory disease activity. These findings should be interpreted cautiously given the modest sample size and limited precision, and small clinically meaningful effects cannot be excluded.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Zübeyir Salis"
    },
    {
      "name": "Léopold Durand"
    },
    {
      "name": "Jacques Morel"
    },
    {
      "name": "Cédric Lukas"
    },
    {
      "name": "Claire Immediato Daien"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/05t8rczmrs40f.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jbspin.2026.106143",
  "fulltext_url": null,
  "id": "05t8rczmrs40f",
  "issns": [
    "1297-319X"
  ],
  "landing_url": "https://hal.science/hal-05756446v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2745|Rheumatoid Arthritis Research and Therapies"
    ]
  ],
  "openalex": "W7213662925",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S1297319X26001120/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/05t8rczmrs40f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "hal-05756446",
      "source": "hal",
      "url": "https://hal.science/hal-05756446v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Weight change and longitudinal disease activity in rheumatoid arthritis: a real-world cohort study",
  "title_text": "Weight change and longitudinal disease activity in rheumatoid arthritis: a real-world cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/05t8rczmrs40f",
  "venue": "Joint Bone Spine",
  "versions": []
}