{
  "abstract": "Background and objectives\n\nAlcohol Use Disorder (AUD) is a global issue with a significant financial impact on health. The main objective of this study was to assess the chronic effect of alcohol on the composition and diversity of intestinal microbiota in AUD patients.Methods\n\nProspective cohort study in patients hospitalized for AUD treatment. Demographic, clinical, and laboratory data and inflammatory markers were assessed at the time of hospital admission for AUD-T1-group and in the control group, as well evaluation of the gut microbiota composition, while the AUD-T2-group was assessed at the discharge from hospital treatment.Results\n\n50 participants were included in the control group and 47 admitted for AUD treatment. The mean age in the AUD-T1-group was 49.3 years, all male. Mieloperoxidase concentration was significantly higher in AUD-T1-group compared to control (P<0.001). The opposite was observed for E-selectin (P<0.001). Global alpha diversity was different among the control, AUD-T1 and AUD-T2 groups, ACE index (P<0.004), Shannon index (P<0.017), observed taxa (P=0.002). The LEfSe algorithm identified a higher abundance of Faecalibacterium, Bacteroides, Agathobacter, and Ruminococcaceae unclassified in control compared to the AUD-T1. There were no differences in the abundance of bacterial genera between the AUD-T1 and AUD-T2 groups.Conclusion\n\nPatients with AUD exhibit changes in intestinal microbiota composition, potentially associated with low-grade inflammation and functional alterations that contribute to the development of diseases. The composition of intestinal microbiota and its bioactive metabolites may serve as novel therapeutic targets for the treatment of AUD.",
  "abstract_shown": true,
  "affiliations": [
    "Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Gastroenterologia e Hepatologia, Porto Alegre, RS, Brasil.",
    "Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório Experimental de Hepatologia e Gastroenterologia, Porto Alegre, RS, Brasil.",
    "Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Porto Alegre, RS, Brasil.",
    "Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Porto Alegre, RS, Brasil.",
    "Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Centro de Pesquisas sobre Drogas e Álcool e Centro Colaborador em Álcool e Drogas, Porto Alegre, RS, Brasil.",
    "Hospital de Clínicas de Porto Alegre, Divisão de Gastroenterologia, Porto Alegre, RS, Brasil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Rutiane Ullmann Thoen",
      "orcid": "0000-0001-8174-0366"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Larisse Longo",
      "orcid": "0000-0002-4453-7227"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Bruno de Souza Basso",
      "orcid": "0000-0001-5331-6787"
    },
    {
      "affs": [
        2
      ],
      "name": "Pabulo Henrique Rampelotto",
      "orcid": "0000-0002-8992-9697"
    },
    {
      "affs": [
        3
      ],
      "name": "Anne Orgler Sordi",
      "orcid": "0000-0002-4629-1646"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Félix Henrique Paim Kessler",
      "orcid": "0000-0001-7059-2564"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Lisia Von Diemen",
      "orcid": "0000-0001-9228-7114"
    },
    {
      "affs": [
        0,
        1,
        5
      ],
      "name": "Mário Reis Álvares-DA-Silva",
      "orcid": "0000-0002-5001-246X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/06hvy2y64c7zs.bib",
  "cited_by": 0,
  "doi": "10.1590/s0004-2803.24612025-144",
  "fulltext_url": "https://europepmc.org/articles/PMC13721022",
  "id": "06hvy2y64c7zs",
  "issns": [
    "0004-2803",
    "1678-4219"
  ],
  "landing_url": "https://europepmc.org/article/MED/42961248",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "ORIGINAL ARTICLE/Experimental Medicine"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7223663482",
  "pdf_url": "https://europepmc.org/articles/PMC13721022?pdf=render",
  "pmcid": "PMC13721022",
  "pmid": "42961248",
  "published": "2026-10-26",
  "publisher": "Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e outras Especialidades",
  "ris": "https://research.draconitic.com/paper/06hvy2y64c7zs.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42961248",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42961248"
    },
    {
      "first_seen": "2026-11-03T12:21:47Z",
      "native_id": "PMC13721022",
      "source": "pmc",
      "url": "https://doi.org/10.1590/s0004-2803.24612025-144"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "DYSBIOSIS OF GUT MICROBIOTA IN PATIENTS HOSPITALIZED FOR THE TREATMENT OF ALCOHOL USE DISORDER.",
  "title_text": "DYSBIOSIS OF GUT MICROBIOTA IN PATIENTS HOSPITALIZED FOR THE TREATMENT OF ALCOHOL USE DISORDER.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:47Z",
  "url": "https://research.draconitic.com/paper/06hvy2y64c7zs",
  "venue": "Arquivos de gastroenterologia",
  "versions": []
}