{
  "abstract": "Post-transplant diabetes mellitus (PTDM) is the most frequent metabolic complication after liver transplantation. The role of triglyceride-rich lipoprotein cholesterol (TRL-c) in PTDM risk remains poorly defined. We characterized TRL-c in liver transplant recipients (LTRs) from the TransplantLines cohort (NCT03272841) compared to the general population (PREVEND cohort; NCT03073018) and evaluated its association with incident PTDM. We compared 367 adult LTRs and 4,837 PREVEND participants with TRL-c measurements derived from total cholesterol, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c), all measured by nuclear magnetic resonance spectroscopy. Incident PTDM was assessed using Cox models and adjusted for clinically relevant covariates. Compared with PREVEND participants, LTRs had higher triglycerides, TRL-c, and HDL-c but lower total and LDL-c, irrespective of baseline diabetes status. Among LTRs, TRL-c was highest in those with pre-existing diabetes and lowest in those who remained non-diabetic. During a median follow-up of 7.1 years (IQR 6.2–7.8), 31 (12.6%) LTRs developed PTDM. Incidence was highest in the top TRL-c tertile (p = 0.016). Each 1-SD increase in TRL-c was associated with a 64% higher PTDM risk, independent of other risk factors. TRL-c may help risk stratification after transplant, given it likely captures a dyslipidemic phenotype not represented by conventional lipid measurements.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen",
    "Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen",
    "Labcorp",
    "Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen",
    "Division of Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mateo Chvatal-Medina"
    },
    {
      "affs": [
        1
      ],
      "name": "Adrian Post"
    },
    {
      "affs": [
        2
      ],
      "name": "Margery A. Connelly"
    },
    {
      "affs": [
        0
      ],
      "name": "Yakun Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Han Moshage"
    },
    {
      "affs": [
        1
      ],
      "name": "Stephan J. L. Bakker"
    },
    {
      "affs": [
        1
      ],
      "name": "Anna M. Posthumus"
    },
    {
      "affs": [
        3
      ],
      "name": "Vincent E. de Meijer"
    },
    {
      "affs": [
        0
      ],
      "name": "Hans Blokzijl"
    },
    {
      "affs": [
        4
      ],
      "name": "Robin Dullaart"
    },
    {
      "name": "Transplant Lines Investigators"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/06jsyqzbqnwmp.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-62929-x",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-62929-x",
  "id": "06jsyqzbqnwmp",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-62929-x",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2746|Organ Transplantation Techniques and Outcomes"
    ]
  ],
  "openalex": "W7169607749",
  "pdf_url": "https://www.nature.com/articles/s41598-026-62929-x_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/06jsyqzbqnwmp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:55Z",
      "native_id": "fe04ae30b7ab485b80ac0ac098169a8c",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-62929-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Organ Transplantation Techniques and Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "Triglyceride-rich lipoprotein cholesterol is elevated in liver transplant recipients and associated with post-transplant diabetes",
  "title_text": "Triglyceride-rich lipoprotein cholesterol is elevated in liver transplant recipients and associated with post-transplant diabetes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:55Z",
  "url": "https://research.draconitic.com/paper/06jsyqzbqnwmp",
  "venue": "Scientific Reports",
  "versions": []
}