{
  "abstract": "Background: Temporal muscle thickness (TMT), an imaging-based surrogate of skeletal muscle mass and sarcopenia, has emerged as a potential prognostic marker in glioblastoma. However, its prognostic value in patients with isocitrate dehydrogenase wild-type (IDH-wt) glioblastoma remains uncertain. This meta-analysis evaluated the association between baseline TMT and survival outcomes in this population.\n\nMethods: PubMed, Embase, and Web of Science were searched from inception to June 9, 2026. Cohort studies evaluating baseline TMT in relation to overall survival (OS) and/or progression-free survival (PFS) in patients with newly diagnosed IDH-wt glioblastoma were included. Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using random-effects models accounting for the influence of potential heterogeneity.\n\nResults: Twelve retrospective cohort studies involving 2,762 patients were included. Low baseline TMT was significantly associated with poorer OS (12 studies; HR, 1.81; 95% CI: 1.38 to 2.37; p < 0.001; I² = 81%) and PFS (4 studies; HR, 1.65; 95% CI: 1.37 to 1.99; p < 0.001; I² = 15%). The association with poorer OS remained significant across subgroups defined by geographic region, mean age, TMT cutoff method and value, follow-up duration, analytic model, MGMT methylation adjustment, and study quality, with no significant between-subgroup differences. Meta-regression identified mean age as a significant moderator (coefficient, −0.064; 95% CI, −0.122 to −0.006; p =0.03) for the association between low TMT and poor OS.\n\nConclusions: Low baseline TMT is associated with poorer OS and PFS in patients with newly diagnosed IDH-wt glioblastoma, although substantial between-study heterogeneity for OS warrants cautious interpretation. TMT may serve as a complementary prognostic marker, but further prospective studies are needed to establish its independent prognostic and clinical utility.\n\nSystematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/ , identifier CRD420261455834.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Medicine, The First Clinical College of Anhui Medical University",
    "Department of Neurosurgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaxuan Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Quanbin Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yi Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/06ngwxq3t0dvj.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1944073",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1944073/full",
  "id": "06ngwxq3t0dvj",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1944073/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/06ngwxq3t0dvj.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:46Z",
      "native_id": "10.3389/fonc.2026.1944073",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1944073/full"
    },
    {
      "first_seen": "2026-11-04T14:20:47Z",
      "native_id": "170b9bbb0e9f47508b774510f3f082b4",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fonc.2026.1944073"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC254-282",
      "subfield": "oncology"
    }
  ],
  "title": "Temporal muscle thickness and the survival of patients with IDH-wildtype glioblastoma: a meta-analysis",
  "title_text": "Temporal muscle thickness and the survival of patients with IDH-wildtype glioblastoma: a meta-analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T14:20:12Z",
  "url": "https://research.draconitic.com/paper/06ngwxq3t0dvj",
  "venue": "Frontiers in Oncology",
  "versions": []
}