{
  "abstract": "BACKGROUND: This study evaluated the prognostic impact of left ventricular (LV) apical aneurysm identified by transthoracic echocardiography (TTE) in a Japanese cohort with hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: We retrospectively enrolled 369 consecutive HCM patients from 2 centers (2016-2023). LV apical aneurysm was defined on TTE as a discrete, thin-walled dyskinetic/akinetic apical outpouching with a wide neck. Primary outcomes were all-cause death and cardiovascular (CV) death. Secondary outcomes were hospitalization for worsening heart failure, systemic embolism, sustained ventricular tachycardia (VT), and sudden cardiac death (SCD)-equivalent events (resuscitated cardiac arrest or appropriate implantable cardioverter defibrillator therapy). LV apical aneurysm was present in 47 of 369 patients (12.7%). There were no significant between-group differences in all-cause death (log-rank P=0.162) or CV death (P=0.103). Patients with LV apical aneurysm more frequently had baseline sustained VT and SCD-equivalent events; however, Kaplan-Meier analyses indicated no significant differences between groups in incident sustained VT and SCD-equivalent events after enrollment. In multivariable Cox models, age, B-type natriuretic peptide (BNP), and SCD-equivalent events were independently associated with all-cause death; BNP and SCD-equivalent events were independently associated with CV death. CONCLUSIONS: In this cohort, echocardiography-identified LV apical aneurysm was associated with a greater burden of baseline arrhythmic events, but not higher mortality. TTE provides a practical means of identifying this phenotype. BNP and SCD-equivalent events were more closely associated with mortality.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Junya Komatsu"
    },
    {
      "name": "Naoki Arima"
    },
    {
      "name": "Yuri Ochi"
    },
    {
      "name": "Toru Kubo"
    },
    {
      "name": "Yu-ki Nishimura"
    },
    {
      "name": "Hayato Hosoda"
    },
    {
      "name": "Ryu-ichiro Imai"
    },
    {
      "name": "Yoko Nakaoka"
    },
    {
      "name": "Shinji Mito"
    },
    {
      "name": "Shu-ichi Seki"
    },
    {
      "name": "Sho-ichi Kubokawa"
    },
    {
      "name": "Hiroaki Kitaoka"
    },
    {
      "name": "Kazuya Kawai"
    },
    {
      "name": "Naohisa Hamashige"
    },
    {
      "name": "Yoshinori L. Doi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/06rnz4v7gc27s.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-26-0311",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0311/_article",
  "id": "06rnz4v7gc27s",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0311/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2705|Cardiomyopathy and Myosin Studies"
    ]
  ],
  "openalex": "W7220472658",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0311/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/06rnz4v7gc27s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-26-0311",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0311/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiomyopathy and Myosin Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Prognostic Impact of Left Ventricular Apical Aneurysm Identified by Echocardiography in Hypertrophic Cardiomyopathy ― A Multicenter Retrospective Study in Japan ―",
  "title_text": "Prognostic Impact of Left Ventricular Apical Aneurysm Identified by Echocardiography in Hypertrophic Cardiomyopathy ― A Multicenter Retrospective Study in Japan ―",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/06rnz4v7gc27s",
  "venue": "Circulation Journal",
  "versions": []
}