{
  "abstract": "The extent to which periodontitis-associated transcriptional patterns correspond to oral mucosal responses to radiotherapy remains unclear. We integrated three human transcriptomic cohorts to characterize this correspondence and its analytical stability using differential-expression, signature-score, and gene-set analyses. In GSE10334, a patient-blocked analysis of 247 gingival profiles identified 111 differentially expressed genes, of which 104 retained significance across sensitivity analyses. In the independent GSE173078 cohort, 95 of 97 mapped genes showed concordant effect directions (Spearman ρ = 0.824). Twenty-three genes met replication criteria in the fully adjusted model, compared with none in the batch-only model. The signature score was higher in periodontitis than in healthy gingiva (β = 1.66; 95% confidence interval, 0.40–2.93). In GSE103412, comprising eight patients with seven post-treatment observations, neither the 18 mapped replicated periodontal genes nor longitudinal signature scores met significance criteria. CAMERA detected enrichment of the periodontitis-upregulated set during and after radiotherapy with intergene correlation fixed at 0.01 (false discovery rate [FDR] = 0.00124 and 4.70 × 10−6), but not with data-estimated correlation (FDR = 0.360 and 0.177). Expression-matched random-set comparisons indicated signals exceeding the specified background without establishing disease specificity. Twenty-one overlapping Gene Ontology terms showed concordant cross-cohort enrichment under the original analytical specification. Cellular-proxy analyses suggested contributions from tissue composition or cellular state, while exploratory associations with mucositis severity were nonsignificant after correction. These findings identify partial, analytically dependent transcriptional correspondence without establishing that periodontitis increases susceptibility to radiation-induced mucositis or provides clinical predictive value. Prospective studies incorporating periodontal assessment and concurrent molecular and clinical measurements are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou 510515, China",
    "Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China",
    "Nanfang Hospital, Southern Medical University, Guangzhou 510515, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ziqiang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ronghan Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Feiyuan Xue"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaodan Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Shichun Gao"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhendong Gong"
    },
    {
      "affs": [
        1
      ],
      "name": "Lin Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Runting Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yanni Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Guozhu Xie"
    },
    {
      "affs": [
        1
      ],
      "name": "Lanfang Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/06v3t9heqe6rh.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219976",
  "fulltext_url": null,
  "id": "06v3t9heqe6rh",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9976",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-07",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/06v3t9heqe6rh.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:27Z",
      "native_id": "10.3390/ijms27219976",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9976"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Periodontitis-Associated Transcriptional Signatures and Their Correspondence with Oral Mucosal Responses to Radiotherapy: A Cross-Cohort Analysis",
  "title_text": "Periodontitis-Associated Transcriptional Signatures and Their Correspondence with Oral Mucosal Responses to Radiotherapy: A Cross-Cohort Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:27Z",
  "url": "https://research.draconitic.com/paper/06v3t9heqe6rh",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}