{
  "abstract": "Background: Cholangiocarcinoma (CCA) is an inflammation-associated malignancy with limited benefit from HER2-targeted therapy. Whether psoriasis is causally linked to CCA and how AP1S3 contributes remain unclear. Methods: We performed exploratory two-sample Mendelian randomization (MR), integrated bulk and single-cell transcriptomes, and used CCA cell lines and xenografts to examine AP1S3 and HER2 trafficking. Results: Strict MR (8 IVs; MHC excluded) gave an OR of 1.00 (95% CI 0.83–1.21; p = 0.98); the relaxed-threshold estimate (OR 1.12, 1.01–1.25; p = 0.037) was not robust (independent OR 1.05, 0.96–1.14; p = 0.30). IL-17A/TNF-α increased AP1S3 in CCA cells and activated NF-κB/RELA, but direct RELA binding was not demonstrated. AP1S3 was associated with a SCEL+ squamous-like program. AP1S3 co-precipitated with HER2 via EIPDLL (residues 930–935, kinase domain) and modulated HER2 trafficking; direct binding, isoform specificity and active recycling were not established. Conclusions The psoriasis–CCA association is inconclusive. AP1S3 is a candidate inflammatory regulator of HER2 trafficking and requires direct binding, loss-of-function and clinical validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410000, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chen Shen"
    },
    {
      "affs": [
        0
      ],
      "name": "Ronglin Xu",
      "orcid": "0009-0008-7201-0431"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongxiang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhongtao Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Xin"
    },
    {
      "affs": [
        0
      ],
      "name": "Tiantian Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Heng Zou"
    },
    {
      "affs": [
        0
      ],
      "name": "Zijian Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Wen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/06vs18pwqqha4.bib",
  "cited_by": 0,
  "doi": "10.3390/cells15212039",
  "fulltext_url": null,
  "id": "06vs18pwqqha4",
  "issns": [
    "2073-4409"
  ],
  "landing_url": "https://www.mdpi.com/2073-4409/15/21/2039",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/06vs18pwqqha4.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:28Z",
      "native_id": "10.3390/cells15212039",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4409/15/21/2039"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2073-4409",
      "subfield": "cell-biology"
    }
  ],
  "title": "AP1S3 Promotes Proliferation and Invasion of Cholangiocarcinoma Cells and Modulates HER2 Trafficking",
  "title_text": "AP1S3 Promotes Proliferation and Invasion of Cholangiocarcinoma Cells and Modulates HER2 Trafficking",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:28Z",
  "url": "https://research.draconitic.com/paper/06vs18pwqqha4",
  "venue": "Cells",
  "versions": []
}