{
  "abstract": "Pulmonary arterial hypertension (PAH) is a devastating disease driven largely by oxidative stress and inflammation. The pulmonary arterial endothelium plays a key role in PAH pathogenesis. In this study, we developed novel poly(lactic-co-glycolic acid) (PLGA)-based lutein nanoparticles coated with a Vascular Cell Adhesion Molecule-1 (VCAM-1) antibody to target pulmonary arterial endothelial cells (PAECs) associated with PAH. Lutein, a potent antioxidant and anti-inflammatory carotenoid, served as the model drug. The lutein nanoparticles were produced by nanoprecipitation, followed by surface modification with VCAM-1 antibody. Physicochemical characterization and cellular efficacy studies were performed to assess the potential of the formulation. The studies revealed the production of nanoparticles with an average size of approximately 170 nm that exhibited specificity for PAH patient-derived PAECs (PAH-PAECs) and antioxidant and anti-inflammatory properties. Moreover, the nanoparticles did not exhibit significant cellular toxicity toward healthy PAECs. This proof-of-principle study demonstrates the therapeutic potential of targeted nanoparticles for the treatment of PAH.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Mechanical Engineering, University of Michigan-Dearborn, 4901 Evergreen Road, Dearborn, MI 48128, USA",
    "Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA",
    "Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA",
    "Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gabriel Floarea"
    },
    {
      "affs": [
        0
      ],
      "name": "Nasser Assi"
    },
    {
      "affs": [
        0
      ],
      "name": "Maytham Ismail",
      "orcid": "0000-0001-7625-9076"
    },
    {
      "affs": [
        0
      ],
      "name": "Anderson Gattis"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Tadanori Mammoto",
      "orcid": "0009-0002-0985-0856"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Akiko Mammoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Mathumai Kanapathipillai",
      "orcid": "0000-0001-8748-6848"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/06x4wv1nf9w3s.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31193511",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666496/?tool=EBI",
  "id": "06x4wv1nf9w3s",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13666496",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7216278349",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666496/pdf/?tool=EBI",
  "pmcid": "PMC13666496",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/06x4wv1nf9w3s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "PMC:PMC13666496",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13666496"
    },
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31193511",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/19/3511"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Development of a Novel Nanoparticle Targeting Endothelial Cells from Patients with Pulmonary Arterial Hypertension",
  "title_text": "Development of a Novel Nanoparticle Targeting Endothelial Cells from Patients with Pulmonary Arterial Hypertension",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:42Z",
  "url": "https://research.draconitic.com/paper/06x4wv1nf9w3s",
  "venue": "Molecules (Basel, Switzerland)",
  "versions": []
}