{
  "abstract": "Objective: To select, through a Delphi consensus process, the clinical items most relevant to pre‐test probability of asthma (PTPA) in children undergoing methacholine challenge test (MCT) and to explore their association with expert‐estimated PTPA.\n\nWorking Hypothesis: Delphi‐selected items are associated with PTPA estimated independently by pediatric pulmonologists.\n\nStudy Design: Three‐round e‐Delphi, followed by a retrospective analysis of item association with expert‐estimated PTPA. Patient‐subject selection: A database of 92 children referred for MCT at a tertiary center.\n\nMethodology: A steering committee proposed 11 candidate items, rated by 23 experts (consensus threshold ≥ 80%). Five pediatric pulmonologists, blinded to MCT results and not involved in the Delphi, independently estimated PTPA from clinical history. Agreement was assessed with intraclass correlation coefficients (ICC). Associations between retained items and mean PTPA were assessed using a multivariable linear regression.\n\nResults: Ten items were retained (nine reached consensus; pneumonia/atelectasis was retained by steering‐committee judgment). Single‐rater ICC was 0.78 (95% CI 0.70–0.85); average‐measures ICC was 0.95 (95% CI 0.92–0.97). Multivariable linear regression retained all ten items; each positively associated with PTPA. The strongest associations were seen with wheezing after age 3 years (β 15, 95% CI 7.4–23), wheezing within the last 3 years (β 14, 95% CI 6.4–22) and complete response to anti‐asthma treatment with relapse after treatment cessation (β 34, 95% CI 27–41).\n\nConclusion: Delphi consensus identified ten clinically relevant items, all associated with expert‐estimated PTPA. As the outcome was expert judgement rather than confirmed asthma, diagnostic value remains unestablished; outcome‐based studies are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Sorbonne Université, APHP, Hôpital Armand Trousseau, Unité Fonctionnelle d'Explorations Fonctionnelles Respiratoire et Somnologie Paris Île‐de‐France France",
    "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatria Pneumoinfettivologia Milan Lombardy Italy",
    "Département de Santé Publique Sorbonne Université, INSERM, Sorbonne Public Health Institute, Team PEPITES, AP‐HP, Hôpital Pitié Salpêtrière Paris Île‐de‐France France",
    "INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique Paris Île‐de‐France France",
    "INSERM U938, Centre de Recherche Saint Antoine Paris Île‐de‐France France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tahani Ibrahim",
      "orcid": "0009-0009-3490-5813"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alessia Mariani",
      "orcid": "0000-0002-8201-4873"
    },
    {
      "affs": [
        2
      ],
      "name": "Maxime Beydon",
      "orcid": "0000-0003-4924-093X"
    },
    {
      "affs": [
        0
      ],
      "name": "Juliette Dardenne",
      "orcid": "0009-0009-3614-2143"
    },
    {
      "affs": [
        0
      ],
      "name": "Marc Koskas"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandra Costea",
      "orcid": "0009-0007-3759-0234"
    },
    {
      "affs": [
        0
      ],
      "name": "Lucia Maingot"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Jessica Taytard",
      "orcid": "0000-0002-7552-3880"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Nicole Beydon",
      "orcid": "0000-0002-6417-382X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/06zn2t3ybvvy1.bib",
  "cited_by": 0,
  "doi": "10.1002/ppul.71903",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732096/",
  "id": "06zn2t3ybvvy1",
  "issns": [
    "8755-6863",
    "1099-0496"
  ],
  "landing_url": "https://doi.org/10.1002/ppul.71903",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2740|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7225227679",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ppul.71903",
  "pmcid": "PMC13732096",
  "pmid": "42978395",
  "published": "2026-11-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/06zn2t3ybvvy1.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:08Z",
      "native_id": "PMC13732096",
      "source": "pmc",
      "url": "https://doi.org/10.1002/ppul.71903"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Asthma and respiratory diseases",
      "subfield": "general"
    }
  ],
  "title": "A Delphi‐Based Item Set for Pre‐Test Asthma Probability Assessment in Children Undergoing Methacholine Challenge Test",
  "title_text": "A Delphi‐Based Item Set for Pre‐Test Asthma Probability Assessment in Children Undergoing Methacholine Challenge Test",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:08Z",
  "url": "https://research.draconitic.com/paper/06zn2t3ybvvy1",
  "venue": "Pediatric Pulmonology",
  "versions": []
}