{
  "abstract": "The heterogenisation of chiral organocatalysts remains a key strategy for developing sustainable and recyclable chemical processes. However, long-term stability is often compromised by catalyst leaching and deactivation. In this work, we present a combined computational and experimental study of the deactivation pathways in an ester-linked heterogeneous thiourea/tertiary amine organocatalyst. By identifying the fundamental causes of activity loss, we establish a rational design framework for developing a more robust, high-performance triazole-linked heterogeneous catalyst with extended lifetime and improved reusability.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, United Kingdom, OX1 3TA",
    "Department of Chemistry, Faculty of Science and Engineering",
    "Swansea University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Adrián López-Francés"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Aitor Maestro",
      "orcid": "0000-0003-4726-9675"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0705vm9f9kbwf.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15007046/v2",
  "fulltext_url": null,
  "id": "0705vm9f9kbwf",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15007046/v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Asymmetric Synthesis and Catalysis"
    ]
  ],
  "openalex": "W7224128126",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/0705vm9f9kbwf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.26434/chemrxiv.15007046",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15007046/v2"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Asymmetric Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "Mitigating Catalyst Leaching and Deactivation in Heterogeneous Hydrogen-Bonding/Tertiary Amine Chiral Organocatalysts",
  "title_text": "Mitigating Catalyst Leaching and Deactivation in Heterogeneous Hydrogen-Bonding/Tertiary Amine Chiral Organocatalysts",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/0705vm9f9kbwf",
  "venue": "ChemRxiv",
  "versions": []
}