{
  "abstract": "Preterm birth is associated with breakdown of maternal–fetal tolerance and remains the leading cause of global mortality in young children. However, the role of self-reactive antibodies has been limited to a handful of pathogenic allo- and autoantibodies linked to pregnancy complications. Here we identify a shared autoreactive signature of pregnancy in pregnant sera (n = 2,719) relative to never-pregnant controls (n = 130), using proteome-wide autoantibody profiling. Across eight human pregnancy cohorts, we define autoreactivities associated with preterm birth by comparing preterm (n = 688) and term (n = 1,505) pregnancies. Within the signature, antibodies to IL1 receptor antagonist (IL1RA) induce resorption, inflammation and vascular malperfusion in pregnant mice. IL1RA localizes to placental endothelial adherens junctions, suggesting a role in vascular integrity. These findings identify a term pregnancy humoral immune program and shared changes preceding preterm delivery, including anti-IL1RA, which may have direct pathogenic consequences.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA USA",
    "Department of Surgery, University of California San Francisco, San Francisco, CA USA",
    "Center for Maternal-Fetal Precision Medicine, University of California San Francisco, San Francisco, CA USA",
    "The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA USA",
    "Department of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA USA",
    "Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA USA",
    "Chan Zuckerberg Biohub San Francisco, San Francisco, CA USA",
    "Division of Neonatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA USA",
    "UC Berkeley - UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA USA",
    "Diabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA USA",
    "Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA USA",
    "UCSF California Preterm Birth Initiative, San Francisco, CA USA",
    "UCSF Institute for Global Health Studies, San Francisco, CA USA",
    "Immuno-Oncology Program and Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY USA",
    "Department of Pediatrics, University of California San Diego, La Jolla, CA USA",
    "Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN USA",
    "Maternal and Fetal Medicine Department, Institute for Women’s Health, University College London, London, UK",
    "Host-Pathogen Interaction Group and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy",
    "Medical Genetics, Department of Molecular Medicine, University of Pavia, Pavia, Italy",
    "School of Life Sciences, Swiss Federal Institute of Technology, Lausanne, Switzerland",
    "Laboratory of Biochemical-Clinical Analyses, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy",
    "Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy",
    "Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy",
    "Neonatal and Pediatric Intensive Care Unit, Mother, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland",
    "Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland",
    "Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 50,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elze Rackaityte",
      "orcid": "0000-0003-3889-8082"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Beltran Borges"
    },
    {
      "affs": [
        0
      ],
      "name": "Hannah M. Kortbawi"
    },
    {
      "affs": [
        0
      ],
      "name": "Haleigh S. Miller"
    },
    {
      "affs": [
        4
      ],
      "name": "Shirley J. Shao"
    },
    {
      "affs": [
        0
      ],
      "name": "Kelsey C. Zorn",
      "orcid": "0000-0003-1227-2137"
    },
    {
      "affs": [
        5
      ],
      "name": "Colette Caspar",
      "orcid": "0009-0008-6803-1600"
    },
    {
      "affs": [
        4
      ],
      "name": "Rebecca Wong"
    },
    {
      "affs": [
        6
      ],
      "name": "Frank McCarthy",
      "orcid": "0000-0002-7933-6847"
    },
    {
      "affs": [
        6
      ],
      "name": "Joseph S. Creery"
    },
    {
      "affs": [
        3,
        7
      ],
      "name": "Margareta Mayer",
      "orcid": "0000-0003-3423-9127"
    },
    {
      "affs": [
        0
      ],
      "name": "Madhura Raghavan"
    },
    {
      "affs": [
        3,
        7
      ],
      "name": "Elaine Kouame"
    },
    {
      "affs": [
        8
      ],
      "name": "Robert R. Puccinelli"
    },
    {
      "affs": [
        6
      ],
      "name": "Amy L. Kistler",
      "orcid": "0000-0003-1112-719X"
    },
    {
      "affs": [
        9
      ],
      "name": "David J. L. Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Sammer Roach Ganem"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandra DeRisi"
    },
    {
      "affs": [
        0
      ],
      "name": "Quinn Kawaja"
    },
    {
      "affs": [
        6
      ],
      "name": "Chung-Yu Wang",
      "orcid": "0000-0002-2236-0264"
    },
    {
      "affs": [
        6
      ],
      "name": "Aditi Saxena"
    },
    {
      "affs": [
        10,
        11,
        12
      ],
      "name": "Scott Oltman",
      "orcid": "0000-0002-6560-3334"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrew F. Kung"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Sabrina A. Mann"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Anthea Mitchell"
    },
    {
      "affs": [
        4
      ],
      "name": "David Huang"
    },
    {
      "affs": [
        13
      ],
      "name": "Gabrielle Rizzuto",
      "orcid": "0000-0003-3052-0253"
    },
    {
      "affs": [
        10,
        14
      ],
      "name": "Rebecca J. Baer",
      "orcid": "0000-0001-8485-1977"
    },
    {
      "affs": [
        0
      ],
      "name": "Caleigh Mandel-Brehm"
    },
    {
      "affs": [
        15
      ],
      "name": "Kelli K. Ryckman",
      "orcid": "0000-0002-9496-4147"
    },
    {
      "affs": [
        4
      ],
      "name": "Stephanie L. Gaw",
      "orcid": "0000-0003-0891-6964"
    },
    {
      "affs": [
        16
      ],
      "name": "Sara L. Hillman"
    },
    {
      "affs": [
        10,
        11,
        12
      ],
      "name": "Laura L. Jelliffe-Pawlowski"
    },
    {
      "affs": [
        3,
        7
      ],
      "name": "Joanna Halkias",
      "orcid": "0000-0003-0721-8961"
    },
    {
      "affs": [
        4
      ],
      "name": "Nasim C. Sobhani"
    },
    {
      "affs": [
        9
      ],
      "name": "Mark S. Anderson",
      "orcid": "0000-0002-3093-4758"
    },
    {
      "affs": [
        17,
        18,
        19
      ],
      "name": "Francsesca Trespidi",
      "orcid": "0009-0007-7206-6796"
    },
    {
      "affs": [
        20
      ],
      "name": "Claudia Alpini"
    },
    {
      "affs": [
        20
      ],
      "name": "Tiziana Bosoni"
    },
    {
      "affs": [
        20
      ],
      "name": "Riccardo Albertini"
    },
    {
      "affs": [
        21
      ],
      "name": "Camilla Bellingeri",
      "orcid": "0000-0002-9391-8122"
    },
    {
      "affs": [
        21,
        22
      ],
      "name": "Barbara Gardella"
    },
    {
      "affs": [
        17,
        19,
        23,
        24
      ],
      "name": "Alessandro Borghesi",
      "orcid": "0000-0002-8773-9144"
    },
    {
      "affs": [
        25
      ],
      "name": "Nicole Prince",
      "orcid": "0000-0002-8506-1122"
    },
    {
      "affs": [
        25
      ],
      "name": "Jessica Lasky-Su",
      "orcid": "0000-0001-6236-4705"
    },
    {
      "affs": [
        5
      ],
      "name": "Michael R. Wilson",
      "orcid": "0000-0002-8705-5084"
    },
    {
      "affs": [
        4
      ],
      "name": "Marcelle I. Cedars"
    },
    {
      "affs": [
        6
      ],
      "name": "Joshua E. Elias",
      "orcid": "0000-0002-8063-3259"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Tippi C. MacKenzie"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Joseph L. DeRisi",
      "orcid": "0000-0002-4611-9205"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/07rgj9pe9afr5.bib",
  "cited_by": 0,
  "doi": "10.1038/s41590-026-02689-y",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710164/",
  "id": "07rgj9pe9afr5",
  "issns": [
    "1529-2908",
    "1529-2916"
  ],
  "landing_url": "https://doi.org/10.1038/s41590-026-02689-y",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2403|Reproductive System and Pregnancy"
    ]
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  "openalex": "W7221807376",
  "pdf_url": null,
  "pmcid": "PMC13710164",
  "pmid": "42875547",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/07rgj9pe9afr5.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:11Z",
      "native_id": "PMC13710164",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41590-026-02689-y"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Reproductive System and Pregnancy",
      "subfield": "immunology"
    }
  ],
  "title": "Evidence for maternal autoantibodies in the pathogenesis of preterm birth",
  "title_text": "Evidence for maternal autoantibodies in the pathogenesis of preterm birth",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:11Z",
  "url": "https://research.draconitic.com/paper/07rgj9pe9afr5",
  "venue": "Nature Immunology",
  "versions": []
}