{
  "abstract": "Background: Ruptured sinus of Valsalva aneurysm (RSVA) following tetralogy of Fallot (TOF) repair is exceedingly rare, with only isolated cases reported. Case Summary: A 53-year-old man with TOF repaired in infancy presented with NYHA functional class IV heart failure. Cardiac computed tomography showed a ruptured right sinus of Valsalva (28.1 × 33.5 mm) draining into the main pulmonary artery. Cardiac catheterization confirmed a left-to-right shunt (pulmonary-to-systemic flow ratio, 2.6:1) with normal pulmonary vascular resistance. Given the prohibitive surgical risk, a 25-mm Harmony pulmonary valve was deployed, achieving complete RSVA occlusion, restoring pulmonary valve competence, and reducing right ventricular pressure. Functional status improved to NYHA functional class II. Discussion: We describe a novel transcatheter approach in repaired TOF, simultaneously addressing RSVA and severe pulmonary regurgitation in a single intervention. Take-Home Messages: RSVA should be suspected in adults with repaired TOF presenting with unexplained heart failure. Transcatheter closure with a Harmony valve may be feasible in carefully selected high-risk surgical candidates with suitable anatomy and concomitant pulmonary valve disease.",
  "abstract_shown": true,
  "affiliations": [
    "Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA",
    "Division of Cardiology, Department of Pediatrics, University of Rochester Medicine, Rochester, New York, USA",
    "Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA; Division of Cardiology, Department of Pediatrics, University of Rochester Medicine, Rochester, New York, USA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gabrielle A. Orie, MS"
    },
    {
      "affs": [
        1
      ],
      "name": "Karunakar Vadlamudi, MD"
    },
    {
      "affs": [
        1
      ],
      "name": "Bayan Issa, MD"
    },
    {
      "affs": [
        1
      ],
      "name": "Joseph D. Kuebler, MD"
    },
    {
      "affs": [
        2
      ],
      "name": "Glenn T. Leonard, MD"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/07sqwm0x21ne4.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jaccas.2026.109900",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2666084926030615",
  "id": "07sqwm0x21ne4",
  "issns": [
    "2666-0849"
  ],
  "landing_url": "https://doi.org/10.1016/j.jaccas.2026.109900",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Case"
    ],
    [
      "heading",
      "Congenital Heart Disease"
    ],
    [
      "lcc",
      "RC666-701"
    ],
    [
      "openalex",
      "2713|Congenital Heart Disease Studies"
    ]
  ],
  "openalex": "W7204646950",
  "pdf_url": "https://www.jacc.org/doi/pdf/10.1016/j.jaccas.2026.109900?download=true",
  "pmcid": "PMC13698948",
  "pmid": "42667284",
  "published": "2026-08-29",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/07sqwm0x21ne4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:25Z",
      "native_id": "13c0e10011a6436c9f790d5193de5b3e",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jaccas.2026.109900"
    },
    {
      "first_seen": "2026-10-30T12:19:38Z",
      "native_id": "PMC13698948",
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      "url": "https://doi.org/10.1016/j.jaccas.2026.109900"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Congenital Heart Disease Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Novel Transcatheter Closure of Ruptured Sinus of Valsalva Aneurysm in Repaired Tetralogy of Fallot",
  "title_text": "Novel Transcatheter Closure of Ruptured Sinus of Valsalva Aneurysm in Repaired Tetralogy of Fallot",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:15Z",
  "url": "https://research.draconitic.com/paper/07sqwm0x21ne4",
  "venue": "JACC: Case Reports",
  "versions": []
}