{
  "abstract": "BACKGROUND: The MIND diet supports healthy cognitive aging. Yet, a challenge remains to identify individuals who do not adhere to the MIND and could be at risk for accelerated cognitive decline. A multi-metabolite biomarker panel could facilitate population screening. OBJECTIVES: To determine and validate a blood metabolomics signature of MIND adherence in a large cohort of older adults, and to estimate its association with subsequent cognitive decline. DESIGN, SETTING AND PARTICIPANTS: Participants were older adults (≥65 years) from the population-based three-City (3C) cohort, free of dementia at study baseline and followed for up to 12 years for cognition, who were included in two case-control samples on cognitive decline nested within two centers (Bordeaux and Dijon cities, n = 838). EXPOSURES: 155 diet-related serum metabolites measured with a multianalyte metabolomics platform. MAIN OUTCOMES AND MEASUREMENTS: The primary outcome was adherence to the MIND diet, assessed in a subsample of 344 participants from Bordeaux center (which underwent the dietary surveys, 24 h recall and food-frequency questionnaire). A metabolomics signature of MIND diet adherence was characterized with penalized regression and a metabolomics score (\"metaboscore\") reflecting the overall MIND biological fingerprint was calculated. The secondary outcome was cognitive decline status (coded as binary: accelerated, vs. null or minimal decline) over follow-up, assessed using repeated cognitive measures in the two case-control samples. The metaboscore was reconstructed and linked to the odds of cognitive decline. RESULTS: Eight metabolites were identified: three were associated with higher MIND adherence (3-hydroxyhippuric acid, 5-hydroxyindole-3-acetic acid, betaine - phenolic acids and amino acid related to plant foods) and five with lower MIND adherence (1-methylhistidine from red meat; cyclo(L-leucyl-L-prolyl) from coffee; tartaric acid from wine; myristoyl-carnitine and dehydroepiandrosterone sulfate, endogenous). The French-MIND metaboscore was linked to lower odds of cognitive decline, although replication was not statistically significant after multivariable adjustment. CONCLUSION: A novel metabolomic signature of the MIND diet was characterized, which may help screen older adults at risk of poor brain nutrition and could support personalized dietary prevention strategies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "name": "Jeanne Neuffer"
    },
    {
      "name": "Raúl González-Domínguez"
    },
    {
      "name": "Sophie Lefèvre-Arbogast"
    },
    {
      "name": "Dorrain Low"
    },
    {
      "name": "Alba Tor-Roca"
    },
    {
      "name": "Catherine Helmer"
    },
    {
      "name": "Andrea Du Preez"
    },
    {
      "name": "Chiara de Lucia"
    },
    {
      "name": "Silvie Ruigrok"
    },
    {
      "name": "Barbara Altendorfer"
    },
    {
      "name": "Ludwig Aigner"
    },
    {
      "name": "Paul Lucassen"
    },
    {
      "name": "Aniko Korosi"
    },
    {
      "name": "Sandrine Thuret"
    },
    {
      "name": "Claudine Manach"
    },
    {
      "name": "Mercè Pallàs"
    },
    {
      "name": "Alex Sánchez-Pla"
    },
    {
      "name": "Cristina Andres-Lacueva"
    },
    {
      "name": "Mireia Urpi-Sarda"
    },
    {
      "name": "Cécilia Samieri"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/07tm9pcch82h1.bib",
  "cited_by": 0,
  "doi": "10.1016/j.tjpad.2026.100670",
  "fulltext_url": null,
  "id": "07tm9pcch82h1",
  "issns": [
    "2274-5807",
    "2426-0266"
  ],
  "landing_url": "https://hal.science/hal-05750068v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
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    [
      "hal",
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    [
      "openalex",
      "2739|Nutritional Studies and Diet"
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  "openalex": "W7208480933",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-15",
  "publisher": "SERDI éd",
  "ris": "https://research.draconitic.com/paper/07tm9pcch82h1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "hal-05750068",
      "source": "hal",
      "url": "https://hal.science/hal-05750068v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.aen",
      "subfield": "nutrition"
    }
  ],
  "title": "Characterization of a metabolomics signature of the brain-health-promoting MIND diet in older persons",
  "title_text": "Characterization of a metabolomics signature of the brain-health-promoting MIND diet in older persons",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/07tm9pcch82h1",
  "venue": "The Journal of prevention of Alzheimer's disease",
  "versions": []
}