{
  "abstract": "This study investigates the chemotherapeutic potential of PtII5CLSS and PtIV5CLSS against breast cancer in vivo. Cell viability was assessed 72 h post-treatment, revealing potent cytotoxic activity with IC50 values of 0.447 μM for PtII5CLSS and 0.922 μM for PtIV5CLSS. Cellular uptake studies used ICP-MS to confirm active transport of both complexes into cells, showing significant accumulation in the nuclear/cytoskeletal fractions. A 28-day toxicity study in female Sprague-Dawley rats demonstrated that escalating doses up to 15 mg/kg (PtII5CLSS) and 30 mg/kg (PtIV5CLSS) caused no mortality nor adverse effects on liver and kidney function. In a chemically induced breast cancer rat model, both complexes significantly reduced tumor weight by 93–100% at doses of 1 and 5 mg/kg, with no observable nephrotoxicity or hepatotoxicity. Histopathological analysis confirmed the reduction or absence of tumors in the majority of the treated animals with PtIV5CLSS (1 mg/kg bw) being the most effective. Toxicity evaluation in sus scrofa pigs showed that PtIV5CLSS was well tolerated at both 1- and 2.5 mg/kg bw, with no mortality, behavioral changes, or signs of acute toxicity. Overall, both PtII5CLSS and PtIV5CLSS demonstrate strong antineoplastic activity against breast cancer with a favorable safety profile, supporting their potential as alternative platinum-based chemotherapeutic agents.",
  "abstract_shown": true,
  "affiliations": [
    "School of Arts and Sciences, Department of Biological Sciences, Lebanese American University, P.O. Box 13-5053, Chouran, Beirut, 1102 2801 Lebanon.",
    "School of Science, Western Sydney University, Locked Bag 1797 Penrith South, 2751 New South Wales, Australia.",
    "Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 13-5053, Chouran, Beirut, 1102 2801 Lebanon.",
    "Alice Ramez Chagoury School of Nursing, Lebanese American University, P.O. Box 13-5053, Chouran, Beirut, 1102 2801 Lebanon.",
    "School of Arts and Sciences, Department of Physical Sciences, Lebanese American University, P.O. Box 13-5053, Chouran, Beirut, 1102 2801 Lebanon."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Omar Hammoud"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maria George Elias",
      "orcid": "0000-0002-1478-7006"
    },
    {
      "affs": [
        0
      ],
      "name": "Amjad Slika"
    },
    {
      "affs": [
        1
      ],
      "name": "Aleen Khoury",
      "orcid": "0000-0002-7139-9536"
    },
    {
      "affs": [
        0
      ],
      "name": "Stephanie Mehanna",
      "orcid": "0000-0002-6741-7842"
    },
    {
      "affs": [
        0
      ],
      "name": "Joelle Abou Chacra"
    },
    {
      "affs": [
        2
      ],
      "name": "Selim Nasser"
    },
    {
      "affs": [
        1
      ],
      "name": "Janice R Aldrich-Wright",
      "orcid": "0000-0002-6943-6908"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Costantine F Daher",
      "orcid": "0000-0002-8275-7263"
    },
    {
      "affs": [
        4
      ],
      "name": "Robin I Taleb",
      "orcid": "0000-0001-8033-6951"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0865kh0kqtfht.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.5c11584",
  "fulltext_url": "https://europepmc.org/articles/PMC13689262",
  "id": "0865kh0kqtfht",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/62402/5445926/Potent-Antineoplastic-Activity-against-Breast",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Metal complexes synthesis and properties"
    ]
  ],
  "openalex": "W7220853498",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c11584",
  "pmcid": "PMC13689262",
  "pmid": "42923595",
  "published": "2026-10-07",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/0865kh0kqtfht.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.5c11584",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/62402/5445926/Potent-Antineoplastic-Activity-against-Breast"
    },
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923595",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923595"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Metal complexes synthesis and properties",
      "subfield": "oncology"
    }
  ],
  "title": "Potent Antineoplastic Activity against Breast Cancer in Vitro and in Vivo of a Chloro-Substituted Polyaromatic Platinum(II) Complex and Its Platinum(IV) Prodrug",
  "title_text": "Potent Antineoplastic Activity against Breast Cancer in Vitro and in Vivo of a Chloro-Substituted Polyaromatic Platinum(II) Complex and Its Platinum(IV) Prodrug",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/0865kh0kqtfht",
  "venue": "ACS Omega",
  "versions": []
}