{
  "abstract": "This study aimed to explore the association between handgrip strength and all-cause mortality risk among patients receiving maintenance peritoneal dialysis (PD). This prospective cohort study enrolled adult patients with kidney failure undergoing PD, with regular follow-up conducted from January 2022 to March 2025. Baseline handgrip strength was the exposure of interest, and all-cause mortality during follow-up was set as the primary endpoint. Kaplan–Meier survival curves with the log-rank test were used to compare survival differences across groups. Multivariable Cox proportional hazards regression models were applied to adjust for potential confounding factors. A total of 258 participants with complete baseline data were included in the final statistical analysis. Overall, 57.8% (149/258) of participants exhibited low handgrip strength. Over the 3-year follow-up period, 3.9% (10/258) of participants were lost to follow-up after switching to hemodialysis, and 18.5% (55/258) experienced all-cause death. Mortality was 28.2% (42/149) in the low handgrip strength group versus 11.9% (13/109) in the normal handgrip strength group, with an absolute mortality difference of 16.3% (95% CI 6.9–25.7%) between groups. Cardiovascular disease accounted for 80.0% of all recorded deaths. Kaplan–Meier survival curves indicated worse survival among participants with low handgrip strength (log-rank test, χ2 = 10.22, P = 0.001). Multivariable Cox proportional hazards regression models adjusting for relevant confounders were applied to assess the association between handgrip strength and all-cause mortality (low vs. normal handgrip strength). After full adjustment for potential confounding factors, low handgrip strength remained significantly associated with higher all-cause mortality risk (HR 2.35, 95% CI 1.25–4.41, P = 0.008). Given cardiovascular disease represented the leading cause of death in this cohort, we performed a sensitivity analysis taking cardiovascular mortality as the primary endpoint. The association between handgrip strength and cardiovascular mortality was consistent with the primary analysis (HR 2.48, 95% CI 1.22–5.03, P = 0.012). Furthermore, a post-hoc sensitivity analysis was conducted using the updated 2025 AWGS age-stratified cut-offs to validate result stability. After rigorous multivariable adjustment, the robust association between low handgrip strength and elevated all-cause mortality risk persisted (HR 6.53, 95% CI 1.56–27.36, P = 0.01). Low handgrip strength is independently correlated with higher all-cause mortality risk in patients receiving maintenance PD. Handgrip strength may serve as a simple, practical prognostic marker for risk stratification in this population.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nephrology, Wenzhou Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Beixia Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Lailiang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Youjun Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Congping Xue"
    },
    {
      "affs": [
        0
      ],
      "name": "Haixue Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Fangfang Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Qun Luo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/08e4qva0t9qcz.bib",
  "cited_by": 1,
  "doi": "10.1038/s41598-026-62747-1",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-62747-1",
  "id": "08e4qva0t9qcz",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-62747-1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2727|Dialysis and Renal Disease Management"
    ]
  ],
  "openalex": "W7169608355",
  "pdf_url": "https://www.nature.com/articles/s41598-026-62747-1_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/08e4qva0t9qcz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:52Z",
      "native_id": "24af1f1fd41547088c54b686668a1a2c",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-62747-1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Dialysis and Renal Disease Management",
      "subfield": "general"
    }
  ],
  "title": "Association between handgrip strength and risk of all-cause mortality in peritoneal dialysis patients: a prospective cohort study",
  "title_text": "Association between handgrip strength and risk of all-cause mortality in peritoneal dialysis patients: a prospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:52Z",
  "url": "https://research.draconitic.com/paper/08e4qva0t9qcz",
  "venue": "Scientific Reports",
  "versions": []
}