{
  "abstract": "Humans and their associated microbes form a multifaceted ecosystem. Gaining mechanistic insight into this system necessitates reductionist models integrating ecological and immunological dimensions. Over the past decade, the gnotobiotic Oligo-Mouse- Microbiota (OMM12) mouse line has exemplified this approach, pairing a standardized consortium of 12 bacterial strains representative of the five major phyla of the mouse microbiota, with the most widely used host background, C57bl/6 mice, in microbiome research. Across numerous studies, this reproducible and experimentally tractable model has enabled the identification of molecular mechanisms underlying colonization resistance, pathogen virulence, microbiota-dependent metabolic and immune pathways, as well as bacterial and bacteriophage dynamics. The modular ability/nature of the OMM12 model may now be further leveraged and refined in different host and microbial dimensions to address remaining gaps in translational microbiome research, positioning it as a reference framework for mechanistic investigations.",
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  "authors": [
    {
      "name": "Devon E Conti"
    },
    {
      "name": "Laurent Debarbieux"
    },
    {
      "name": "Caroline Henrot"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/08n0jsve8fsbk.bib",
  "cited_by": 0,
  "doi": "10.1080/19490976.2026.2725332",
  "fulltext_url": null,
  "id": "08n0jsve8fsbk",
  "issns": [
    "1949-0976",
    "1949-0984"
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  "landing_url": "https://pasteur.hal.science/pasteur-05762241v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
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  "pdf_url": "https://pasteur.hal.science/pasteur-05762241/document",
  "pmcid": null,
  "pmid": "42773683",
  "published": "2026-09-22",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/08n0jsve8fsbk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:40Z",
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      "url": "https://pasteur.hal.science/pasteur-05762241v1"
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  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ee",
      "subfield": "ecology"
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  "title": "The OMM 12 mice: a decade of dissecting host-microbiome interactions",
  "title_text": "The OMM 12 mice: a decade of dissecting host-microbiome interactions",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:40Z",
  "url": "https://research.draconitic.com/paper/08n0jsve8fsbk",
  "venue": "Gut microbes",
  "versions": []
}