{
  "abstract": "Childhood and adolescence are marked by protracted developmental remodeling of cortico-cortical structural connectivity. However, the spatiotemporal variability of white matter connectivity development across the human connectome and its relevance to cognition and psychopathology remains unclear. Using diffusion MRI data from three independent developmental cohorts spanning youth, we identified a robust divergence in structural connectivity maturation along a predefined sensorimotor-association (S-A) connectional axis during youth ( http://connectcharts.cibr.ac.cn ). This developmental continuum ranged from early childhood increases in sensorimotor-sensorimotor connectivity strength to late adolescent increases in association-association connectivity strength, with the transition occurring around age 15. The S-A connectional axis also captured spatial variations in the associations between structural connectivity and both higher-order cognition and general psychopathology. Moreover, group-level developmental trajectories of structural connectivity differed by cognitive and psychopathological levels, with psychopathological effects predominantly observed in association connections. These findings delineate a spatiotemporal continuum of structural connectivity development during youth, providing a normative reference for quantifying developmental variability in psychiatric disorders.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China",
    "Chinese Institute for Brain Research, Beijing, Beijing, China",
    "State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China",
    "Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China",
    "Child Mind Institute, Center for the Integrative Developmental Neuroscience, New York, NY, USA",
    "Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA",
    "School of Psychology, Shandong Normal University, Jinan, China",
    "Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA",
    "Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA",
    "Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. cuizaixu@cibr.ac.cn",
    "Chinese Institute for Brain Research, Beijing, Beijing, China. cuizaixu@cibr.ac.cn"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xiaoyu Xu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hang Yang",
      "orcid": "0000-0002-7349-3366"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jing Cong"
    },
    {
      "affs": [
        3,
        0,
        1
      ],
      "name": "Haoshu Xu",
      "orcid": "0009-0000-5065-9709"
    },
    {
      "affs": [
        4
      ],
      "name": "Jason Kai",
      "orcid": "0000-0002-7074-6348"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shaoling Zhao",
      "orcid": "0000-0003-4050-5065"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yang Li",
      "orcid": "0000-0001-5672-4110"
    },
    {
      "affs": [
        5
      ],
      "name": "Haochang Shou",
      "orcid": "0000-0002-3043-047X"
    },
    {
      "affs": [
        6
      ],
      "name": "Kangcheng Wang",
      "orcid": "0000-0002-3025-8294"
    },
    {
      "affs": [
        7
      ],
      "name": "Valerie J. Sydnor",
      "orcid": "0000-0002-8640-668X"
    },
    {
      "affs": [
        4
      ],
      "name": "Ting Xu",
      "orcid": "0000-0002-0065-3832"
    },
    {
      "affs": [
        8
      ],
      "name": "Fang-Cheng F. Yeh",
      "orcid": "0000-0002-7946-2173"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Zaixu Cui",
      "orcid": "0000-0003-4385-8106"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/08qy8megnhntv.bib",
  "cited_by": 11,
  "doi": "10.1038/s41467-026-73072-6",
  "fulltext_url": null,
  "id": "08qy8megnhntv",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-73072-6",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "2741|Advanced Neuroimaging Techniques and Applications"
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  "pdf_url": null,
  "pmcid": "PMC11212872",
  "pmid": "38948845",
  "published": "2026-05-15",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/08qy8megnhntv.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T13:20:51Z",
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      "url": "https://doi.org/10.1038/s41467-026-73072-6"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Advanced Neuroimaging Techniques and Applications",
      "subfield": "imaging"
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  "title": "Mapping the spatiotemporal continuum of structural connectivity development across the human connectome in youth",
  "title_text": "Mapping the spatiotemporal continuum of structural connectivity development across the human connectome in youth",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:16Z",
  "url": "https://research.draconitic.com/paper/08qy8megnhntv",
  "venue": "Nature Communications",
  "versions": []
}