{
  "abstract": "Background: A family history of breast cancer may impact reproductive choices and decisions about family-building. This study evaluated family-building considerations, plans, and decisional processes among women with a breast cancer family history, and examined sociodemographic, clinical, and psychosocial factors related to decision uncertainty. Methods: Cross-sectional data from the Breast Cancer Family Registry (BCFR) Young Women’s Study were analyzed. Participants were women (18-45 years old) with a breast cancer family history. They completed questionnaires including a Reproductive Choices module. Bivariate analyses and multiple regression evaluated relationships among study variables. Results: Participants (N=471) were on average 30.3 years old (SD=6.7), predominantly non-Hispanic White (75.1%), and over half were childless (58.6%); nearly half (47.8%) desired future children, 16.6% were unsure, and 35.7% did not. Among those interested/unsure (n=303), most considered natural conception (85.8%); many were unsure about alternative options such as embryo genetic testing, donor gametes, surrogacy, and adoption. Between 43–57% endorsed some degree of decision uncertainty. Perceived knowledge about genetic cancer risk and family-building options appeared low overall. In the final model, greater decision uncertainty was associated with having no history of pregnancy, identifying as Ashkenazi Jewish, endorsing concern about a future child's health, lack of concern about family-building timeline, and lower perceived knowledge about genetic cancer risk and family-building options. Conclusions: Among women with a familial risk for breast cancer, decision uncertainty about family-building options is prevalent and is driven by health-related concerns, knowledge gaps, financial barriers, and values-based considerations. Findings can inform targeted decision support interventions for this population.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Alexandra M. Davis"
    },
    {
      "name": "Jennifer Barsky Reese"
    },
    {
      "name": "Esther M. John"
    },
    {
      "name": "Allison W. Kurian"
    },
    {
      "name": "Jennifer S. Ford"
    },
    {
      "name": "Irene L. Andrulis"
    },
    {
      "name": "Sarah V. Colonna"
    },
    {
      "name": "Mary B. Daly"
    },
    {
      "name": "Jeanine Genkinger"
    },
    {
      "name": "Melissa C. Southey"
    },
    {
      "name": "Mary Beth Terry"
    },
    {
      "name": "Catherine Benedict"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0951fy5zwebwd.bib",
  "cited_by": 0,
  "doi": "10.21203/rs.3.rs-10935505/v1",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734230/",
  "id": "0951fy5zwebwd",
  "issns": [
    "2693-5015"
  ],
  "landing_url": "https://doi.org/10.21203/rs.3.rs-10935505/v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1311|BRCA gene mutations in cancer"
    ]
  ],
  "openalex": "W7224929758",
  "pdf_url": "https://www.researchsquare.com/article/rs-10935505/latest.pdf",
  "pmcid": "PMC13734230",
  "pmid": "42990718",
  "published": "2026-10-30",
  "publisher": "American Journal Experts",
  "ris": "https://research.draconitic.com/paper/0951fy5zwebwd.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:51Z",
      "native_id": "PMC13734230",
      "source": "pmc",
      "url": "https://doi.org/10.21203/rs.3.rs-10935505/v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|BRCA gene mutations in cancer",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Reproductive Choices and Family-building Decision Uncertainty Among Young Women at Familial Risk for Breast Cancer",
  "title_text": "Reproductive Choices and Family-building Decision Uncertainty Among Young Women at Familial Risk for Breast Cancer",
  "type": "preprint",
  "updated_at": "2026-11-08T12:23:51Z",
  "url": "https://research.draconitic.com/paper/0951fy5zwebwd",
  "venue": "Research Square",
  "versions": []
}