{
  "abstract": "Cell dynamics has become an emerging field of study, with early works on migration and traction force microscopy (TFM), such as that of Dembo and Wang (1999), describing the mechanisms of cell motility. They studied mammalian fibroblasts on substrates of varying stiffness, showing that tractions strongly depend on substrate rigidity, presenting larger stresses localized mainly at the front and rear of the cell. They described how actin filaments polymerize at the leading edge, generating contractile stresses allowing the cell to retract at the rear.Schunk et al. (2024) focused on endothelial cell (EC) mechanics. They investigated EC contractility, a key behavior in cell migration promoting angiogenesis. Their TFM experiments demonstrated that increasing substrate stiffness leads to higher traction forces whereas decreasing ligand density reduces them. This highlights the importance of extracellular matrix (ECM) composition and cell-matrix binding.In this work, we focus on studying the hybrid endothelial cell line EAhy926 widely used in cardiovascular research, particularly in the study of angiogenesis. We aim to investigate the dynamics of these cells on substrates of varying stiffness by modulating ECM proteins and comparing the resulting behaviors.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Christelle Margossian"
    },
    {
      "name": "Daria Tsvirkun"
    },
    {
      "name": "Valérie M. Laurent"
    },
    {
      "name": "Claude Verdier"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/095yb7ww3g7be.bib",
  "cited_by": 0,
  "doi": "10.46298/mbj.19169",
  "fulltext_url": null,
  "id": "095yb7ww3g7be",
  "issns": [
    "3076-1158"
  ],
  "landing_url": "https://hal.science/hal-05679085v2",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.phys"
    ],
    [
      "hal",
      "1.phys.meca"
    ],
    [
      "hal",
      "2.phys.meca.biom"
    ],
    [
      "openalex",
      "1307|Cellular Mechanics and Interactions"
    ]
  ],
  "openalex": "W7167864253",
  "pdf_url": "https://hal.science/hal-05679085/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Société de Biomécanique",
  "ris": "https://research.draconitic.com/paper/095yb7ww3g7be.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:01Z",
      "native_id": "hal-05679085",
      "source": "hal",
      "url": "https://hal.science/hal-05679085v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Cellular Mechanics and Interactions",
      "subfield": "cell-biology"
    }
  ],
  "title": "Effect of Substrate Stiffness and Adhesion on Endothelial Cell Dynamics",
  "title_text": "Effect of Substrate Stiffness and Adhesion on Endothelial Cell Dynamics",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:01Z",
  "url": "https://research.draconitic.com/paper/095yb7ww3g7be",
  "venue": "Multidisciplinary Biomechanics Journal",
  "versions": []
}