{
  "abstract": "Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder with complex molecular etiology. Since genetic causes account for less than 50% of ASD cases, novel approaches are required to overcome the challenges of characterizing genes and molecular pathways linking risk alleles to phenotype. Here we use RNA-sequencing, 3-dimensional protein-centric chromatin conformation (Hi-ChIP), and whole genome DNA methylation sequencing approaches to investigate hippocampal tissue from an ASD mouse model (Cntnap2 knockout [Cntnap2 KO]) to determine if multi-omic data integration improves the resolution of key molecular pathways contributing to the complex ASD phenotype. Each -omic dataset individually identified disruptions in numerous genes and pathways, providing broad ASD-related insights, such as 1) 699 downregulated genes with an enrichment of neuronal ontological terms; 2) unique chromatin interactions in Cntnap2 KO mice; and 3) that most differentially methylated genes (1220/1659) have a neuronal function. The multi-omic data integration reduced the heterogeneity and refined the data to 43 genes with links to ASD (e.g., Zbtb18, Cttnbp2, Gabbr2). A pathways analysis of these 43 genes identified one gene ontological term: regulation of neuronal synaptic plasticity. These findings are consistent with large scale gene expression studies of human ASD postmortem brain tissue, suggesting that multi-omic data integration can be used to achieve a greater resolution of the heterogeneous ASD molecular etiology.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792 USA",
    "Department of Statistics, University of Wisconsin, Medical Sciences Center, 1300 University Ave Room 1220, Madison, WI 53706 USA",
    "Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792 USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Carolina D. Alberca",
      "orcid": "0000-0001-8599-630X"
    },
    {
      "affs": [
        1
      ],
      "name": "Kwangmoon Park",
      "orcid": "0000-0002-0987-923X"
    },
    {
      "affs": [
        0
      ],
      "name": "Ligia A. Papale"
    },
    {
      "affs": [
        0
      ],
      "name": "Andy Madrid"
    },
    {
      "affs": [
        0
      ],
      "name": "Phillip E. Bergmann"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Sündüz Keleş",
      "orcid": "0000-0001-9048-0922"
    },
    {
      "affs": [
        0
      ],
      "name": "Reid S. Alisch",
      "orcid": "0000-0003-0637-4137"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/09e2hrqbvd5ng.bib",
  "cited_by": 0,
  "doi": "10.1038/s41380-026-03772-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736642/",
  "id": "09e2hrqbvd5ng",
  "issns": [
    "1359-4184",
    "1476-5578"
  ],
  "landing_url": "https://doi.org/10.1038/s41380-026-03772-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2805|Autism Spectrum Disorder Research"
    ]
  ],
  "openalex": "W7171122248",
  "pdf_url": "https://www.nature.com/articles/s41380-026-03772-4.pdf",
  "pmcid": "PMC13736642",
  "pmid": "42502111",
  "published": "2026-07-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/09e2hrqbvd5ng.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:03Z",
      "native_id": "PMC13736642",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41380-026-03772-4"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Autism Spectrum Disorder Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Multi-omic data integration improves the resolution of the molecular etiology of autism in a mouse model",
  "title_text": "Multi-omic data integration improves the resolution of the molecular etiology of autism in a mouse model",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:03Z",
  "url": "https://research.draconitic.com/paper/09e2hrqbvd5ng",
  "venue": "Molecular Psychiatry",
  "versions": []
}