{
  "abstract": "Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape and plasticity of TE expression and how these patterns may inform studies of ASC biological properties and considerations relevant to clinical translations has been lacking. Here, using human adipose-derived mesenchymal stem cells (hADSCs) as an adult stem cell paradigm, we combined transcriptomic profiling with integrative bioinformatics to map the TE expression landscape in hADSCs across multiple biologically and manufacturing-relevant contexts. We examined TE expression dynamics across culture conditions, senescence, and donor-related backgrounds, and found that TE expression patterns in hADSCs were highly plastic in response to environmental cues. Comparative analyses of TE and gene expression showed that TE patterns and dynamics correlated with transcriptomic signatures related to mesenchymal stem/stromal cells (MSCs) biological states. HERV16-int, L1MEh, and MER61E emerged as recurrent, context-responsive TE candidates associated with transcriptional signatures related to MSC immune-related, stemness-related, and senescence-related programs. This work addresses a gap in MSC TE expression profiling and provides a framework for prioritizing candidate TE-expression features with potential relevance to future MSC manufacturing and quality-assessment studies, pending orthogonal and functional validation.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai, 201908, China.",
    "Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Ningxia, 750004, China.",
    "Department of Cardiac and Vascular Surgery, Huaihe Hospital of Henan University, 115 Ximen Street, Kaifeng, Henan, 475000, China.",
    "Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China.",
    "Department of General Practice, Shanghai 411 Hospital, China RongTong Medical Healthcare Group Co., Ltd., Shanghai, 200081, China.",
    "Guangzhou National Laboratory, Guangzhou, 510530, China.",
    "Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.",
    "Center for Biomedical Digital Science, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.",
    "Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. 05849@tongji.edu.cn.",
    "Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China. Cheery_Wang@usst.edu.cn.",
    "Shanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai, 201908, China. 2010588@tongji.edu.cn.",
    "Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China. 2010588@tongji.edu.cn.",
    "Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. 2010588@tongji.edu.cn.",
    "Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China. zhengliang_gao@shu.edu.cn.",
    "China-Japan Friendship Medical Research Institute, School of Medicine, Shanghai University, Shanghai, 200444, China. zhengliang_gao@shu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Xingyu Fu",
      "orcid": "0009-0006-0191-1123"
    },
    {
      "affs": [
        0,
        2,
        4
      ],
      "name": "Qiangwei Cai"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Jingjing Zhao"
    },
    {
      "affs": [
        0,
        1,
        2,
        4
      ],
      "name": "Ying Chen"
    },
    {
      "affs": [
        5
      ],
      "name": "Jiangping He",
      "orcid": "0000-0002-1425-3530"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Ke Hu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yi Yin"
    },
    {
      "affs": [
        6
      ],
      "name": "Wenhan Yang"
    },
    {
      "affs": [
        6
      ],
      "name": "Lian Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Jiayi Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuo Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Fei He"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhenzhou Li"
    },
    {
      "affs": [
        7
      ],
      "name": "Jiekai Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Keqiang Zuo"
    },
    {
      "affs": [
        8
      ],
      "name": "Xianghuai Xu",
      "orcid": "0000-0002-8713-5332"
    },
    {
      "affs": [
        9
      ],
      "name": "Huan Wang",
      "orcid": "0000-0002-1370-3069"
    },
    {
      "affs": [
        10,
        11,
        12
      ],
      "name": "Peibin Dai",
      "orcid": "0009-0007-4898-3615"
    },
    {
      "affs": [
        13,
        14
      ],
      "name": "Zhengliang Gao",
      "orcid": "0000-0001-5788-4095"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/09j8xe8vpw7dc.bib",
  "cited_by": 0,
  "doi": "10.1038/s41420-026-03277-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13720130",
  "id": "09j8xe8vpw7dc",
  "issns": [
    "2058-7716"
  ],
  "landing_url": "https://europepmc.org/article/MED/42957621",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2716|Mesenchymal stem cell research"
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  ],
  "openalex": "W7172274089",
  "pdf_url": "https://europepmc.org/articles/PMC13720130?pdf=render",
  "pmcid": "PMC13720130",
  "pmid": "42957621",
  "published": "2026-08-04",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/09j8xe8vpw7dc.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42957621",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42957621"
    },
    {
      "first_seen": "2026-11-02T12:23:58Z",
      "native_id": "PMC13720130",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41420-026-03277-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Mesenchymal stem cell research",
      "subfield": "human-genetics"
    }
  ],
  "title": "The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance.",
  "title_text": "The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:04Z",
  "url": "https://research.draconitic.com/paper/09j8xe8vpw7dc",
  "venue": "Cell death discovery",
  "versions": []
}