{
  "abstract": "C3 glomerulopathy (C3GP) is a group of rare glomerular diseases histologically characterized by isolated or predominant C3 deposits within glomeruli associated with glomerular inflammation. Dysregulation of complement alternative pathway was shown to be the cornerstone of their pathogenesis. Patients usually display either rare and pathogenic variants in complement genes implicated in alternative pathway regulation or, more often, autoantibodies interacting with components of this pathway. Some of these antibodies stabilize the activity of C3 or C5 convertase – C3 and C5 nephritic factors (C3NeF and C5NeF) –, while others inhibit regulatory proteins such as complement factor H (CFH).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Alistair Baber"
    },
    {
      "name": "Paul Legendre"
    },
    {
      "name": "Sophie Chauvet"
    },
    {
      "name": "Alexandre Karras"
    },
    {
      "name": "Samuel Deshayes"
    },
    {
      "name": "Antoine Huart"
    },
    {
      "name": "Marguerite Vignon"
    },
    {
      "name": "Kathleen Dessaix"
    },
    {
      "name": "Baptiste Hervier"
    },
    {
      "name": "Bruno Legallicier"
    },
    {
      "name": "Nicolas Martin Silva"
    },
    {
      "name": "Véronique Frémeaux-Bacchi"
    },
    {
      "name": "Benjamin Terrier"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/09kk1qayxxc93.bib",
  "cited_by": 3,
  "doi": "10.1016/j.ekir.2023.12.001",
  "fulltext_url": null,
  "id": "09kk1qayxxc93",
  "issns": [
    "2468-0249"
  ],
  "landing_url": "https://hal.science/hal-05750610v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "openalex",
      "2403|Complement system in diseases"
    ]
  ],
  "openalex": "W4389640526",
  "pdf_url": "http://www.kireports.org/article/S2468024923016236/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-15",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/09kk1qayxxc93.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "hal-05750610",
      "source": "hal",
      "url": "https://hal.science/hal-05750610v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Complement system in diseases",
      "subfield": "immunology"
    }
  ],
  "title": "Digital Ischemia as a Rare Manifestation of C3 Glomerulopathy Associated With Monoclonal Gammopathy",
  "title_text": "Digital Ischemia as a Rare Manifestation of C3 Glomerulopathy Associated With Monoclonal Gammopathy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/09kk1qayxxc93",
  "venue": "Kidney International Reports",
  "versions": []
}