{
  "abstract": "Background: Simultaneous controlled release of multiple therapeutics from a single dosage form is a major frontier in modern pharmaceutics and a key strategy for modernizing traditional Chinese medicine. Methods: Using finasteride (FIN) and a Jing-Zhu hybrid Tibetan (JZ) herbal medicine as model agents for prostatitis therapy, we developed a modified tri-fluid electrospinning process to fabricate drug-co-loaded Janus medicated nanofibers. Soluble polyvinylpyrrolidone (PVP) and insoluble ethylcellulose (EC) served as carrier matrices for the dual faces of the Janus architecture, encapsulating JZ herbal medicine and FIN, respectively. A custom-designed spinneret—comprising two parallel stainless steel tubes nested within a plastic sheath—was engineered to enable side-by-side fiber formation. Results: Scanning and transmission electron microscopy confirmed linear morphologies with a definitive side-by-side Janus structure. X-ray diffraction and Fourier Transform Infrared Spectroscopy revealed that all active ingredients were dispersed in an amorphous state, reflecting polymer–drug compatibility. Encapsulation efficiencies reached 96.34 ± 0.47% for FIN and 94.15 ± 0.48% for JZ herbal medicine. A newly devised water-droplet assay demonstrated that almost all the nanofibers exhibited the intended side-by-side configuration, as evidenced by the rapid dissolution of the PVP side. In vitro release studies showed an initial pulsatile burst of JZ herbal medicine followed by a sustained FIN release profile, as suggested by the single-drug-loaded Janus nanofibrous controls. Conclusions: The present Janus nanostructure system, fabricated via a facile co-shell solvent electrospinning process, has the potential to enable the concurrent yet asynchronous delivery of FIN and JZ herbal components within a single nano-dosage form. This conceptual advance expands the toolkit for designing combination nanomedicines, allowing independent modulation of release kinetics for individual drugs to maximize prospective joint efficacy.",
  "abstract_shown": true,
  "affiliations": [
    "School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qilin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Tingyu Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Hailong Dou"
    },
    {
      "affs": [
        0
      ],
      "name": "Deng‐Guang Yu",
      "orcid": "0000-0001-7825-4498"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0a07yjazee1c2.bib",
  "cited_by": 5,
  "doi": "10.3390/pharmaceutics18091160",
  "fulltext_url": null,
  "id": "0a07yjazee1c2",
  "issns": [
    "1999-4923"
  ],
  "landing_url": "https://doi.org/10.3390/pharmaceutics18091160",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Electrospun Nanofibers in Biomedical Applications"
    ]
  ],
  "openalex": "W7213306491",
  "pdf_url": null,
  "pmcid": "PMC13610661",
  "pmid": "42797335",
  "published": "2026-09-15",
  "publisher": "Multidisciplinary Digital Publishing Institute",
  "ris": "https://research.draconitic.com/paper/0a07yjazee1c2.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T13:20:25Z",
      "native_id": "W7213306491",
      "source": "openalex",
      "url": "https://doi.org/10.3390/pharmaceutics18091160"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Electrospun Nanofibers in Biomedical Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Electrospun Integrated Janus Nanofibers for Asynchronous Delivery of Finasteride and Tibetan Medicine",
  "title_text": "Electrospun Integrated Janus Nanofibers for Asynchronous Delivery of Finasteride and Tibetan Medicine",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T13:20:45Z",
  "url": "https://research.draconitic.com/paper/0a07yjazee1c2",
  "venue": "Pharmaceutics",
  "versions": []
}